Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)
Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)
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DOI：
10.1507/endocrj.ej11-0024
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发表时间：
2011-12-01
影响因子：
2
通讯作者：
Karayianni, Christina
中科院分区：
文献类型：
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作者：
Karavanaki, Kyriaki;Karanika, Evangelia;Karayianni, Christina
有研究表明，DKA过程中细胞因子的释放可能导致毛细血管紊乱，从而可能导致其急性临床并发症（如脑水肿或肺水肿）的发展。我们研究了38例新诊断的T1DM合并DKA的儿童，年龄7.68 +/- 3.07岁，在DKA治疗前、治疗期间和治疗后120h的血浆细胞因子IL-1 β（白细胞介素-1 β）、IL-2、IL-6、IL-8、IL-10、tnf - α以及WBC（白细胞计数）、hs-CRP（高敏c反应蛋白）、OH（生长激素）和皮质醇的水平，目的是监测它们在不同时间点和不同DKA严重程度的水平。在DKA治疗前，IL-6、IL-8、IL-10、WBC和皮质醇水平升高，但在DKA治疗后120h内均下降。然后将患者分为两组：a.中度/重度：pH值7.2。中/重度DKA组(ph
It has been suggested that cytokine release during DKA may result in capillary perturbation and thus may contribute to the development of its acute clinical complications (i.e.cerebral or pulmonary edema). We studied in 38 newly diagnosed T1DM children with DKA, aged 7.68 +/- 3.07 years, plasma levels of cytokines IL-1 beta(interleukin-1 beta), IL-2, IL-6, IL-8, IL-10, TNF-alpha (tumour necrosis factor-alpha) and also WBC (white blood cell count), hs-CRP (high sensitivity C-reactive protein), OH (growth hormone) and cortisol, prior to, during and 120h after DKA management, with the aim to monitor their levels at different time-points and in different degrees of DKA severity. Prior to DKA management the levels of IL-6, IL-8, IL-10, WBC and cortisol were elevated, but were all reduced within 120h after DKA management. Then the patients were divided into two groups: a. moderate/severe: pH 7.2. In the group with moderate/severe DKA (ph