Growth and developmental outcome of infants with in-utero exposure to methadone vs buprenorphine
Growth and developmental outcome of infants with in-utero exposure to methadone vs buprenorphine
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DOI：
10.1038/jp.2015.22
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发表时间：
2015-08-01
影响因子：
2.9
通讯作者：
Coyle, M. G.
中科院分区：
文献类型：
--
作者：
Bier, J. B.;Finger, A. S.;Coyle, M. G.
目的：比较宫内暴露于低剂量美沙酮（= 每天 100 毫克）和丁丙诺啡的婴儿的早期生长和发育结果。 研究设计：对在美国马萨诸塞州新贝德福德的 Southcoast 发育儿科诊所接受评估的宫内美沙酮和丁丙诺啡婴儿的回顾性评价已完成。比较各组婴儿期的生长数据和发育测试结果。结果：高剂量美沙酮组的婴儿头围 z 得分较低，阿尔伯塔婴儿运动量表 (AIMS) 平均得分较低。回归结果证实了美沙酮剂量与头围 z 评分和 AIMS 评分之间的相关性。结论：与丁丙诺啡或较低剂量美沙酮相比，接触超过 100 毫克的母亲美沙酮剂量与婴儿头围减小相关，并且可能对婴儿早期运动技能发展产生负面影响。
OBJECTIVE: To compare early growth and developmental outcome of infants with in-utero exposure to low-dose methadone (= 100 mg per day) and buprenorphine.STUDY DESIGN: A retrospective review of infants with in-utero methadone and buprenorphine exposure who were evaluated at the Southcoast Developmental Pediatric clinic in New Bedford, MA, USA was completed. Growth data and developmental testing results during infancy were compared among the groups.RESULT: Infants in the high-dose methadone group had lower head circumference z scores and a lower mean score on the Alberta Infant Motor Scale (AIMS). Regression results confirmed an association between methadone dose and head circumference z score and AIMS score.CONCLUSION: Exposure to maternal methadone dose in excess of 100 mg is associated with a reduction in infant head circumference when compared with buprenorphine or lower dose methadone, and may have a negative impact on motor skill development during early infancy.