Myocardial perfusion imaging with technetium-99m SQ30217: comparison with thallium-201 and coronary anatomy.
Myocardial perfusion imaging with technetium-99m SQ30217: comparison with thallium-201 and coronary anatomy.
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发表时间：
1989-03
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通讯作者：
D. W. Seldin;Lynne L. Johnson;D. K. Blood;Michael J. Muschel;Kevin F. Smith;R. M. Wall;Paul J. Cannon
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作者：
D. W. Seldin;Lynne L. Johnson;D. K. Blood;Michael J. Muschel;Kevin F. Smith;R. M. Wall;Paul J. Cannon
本文用~（99）mTc标记的SQ_（30217）和~（201）TI对10例正常人和20例近期冠状动脉造影证实的冠心病患者的心肌灌注进行了研究。足底201 TI成像遵循标准跑步机运动，平面SQ 30217成像遵循直立自行车运动，进行心绞痛，或在跑步机测试中获得相同的双产品。从注射15 mCi 99 mTc SQ 30217后2 min开始，分别获得3、6和9 min的直立前斜位、30 °左前斜位和60 °左前斜位图像。大约2小时后，在休息时注射第二次15 mCi剂量，并遵循相同的成像方案。未观察到可归因于SQ 30217的不良反应或实验室异常。正常志愿者的所有扫描均被解释为正常。两种试验的定性读数对于检测冠心病患者（SQ 30217 - 16/20，TI - 17/20，p = NS）和识别异常血管（SQ 30217 - 19/45，TI - 21/45，p = NS）同样敏感。两种试剂在1/15支血管中均为假阳性。静息SQ 30217扫描显示10个血管区域持续异常;其中8个位于至少90%狭窄的远端，3个在铊再分布图像上也异常。在14/20例患者的某些视图中，SQ 30217的肝脏摄取使下心尖段模糊，但不干扰异常血管识别。
Myocardial perfusion in ten normal volunteers and 20 patients with coronary artery disease documented by recent coronary arteriography was studied with 99mTc-labeled SQ30217 and 201TI. Plantar 201TI imaging followed standard treadmill exercise and planar SQ30217 imaging followed upright bicycle exercise, performed to angina, or the same double product achieved on the treadmill test. Upright anterior, 30 degrees left anterior oblique, and 60 degrees left anterior oblique images were obtained for 3, 6, and 9 min, respectively, starting 2 min after injection of 15 mCi of 99mTc SQ30217. A second 15-mCi dose was injected at rest approximately 2 hr later, and the same imaging protocol was followed. No adverse reactions or laboratory abnormalities attributable to SQ30217 were observed. All scans on the normal volunteers were interpreted as normal. Qualitative readings of both tests were equally sensitive for detecting patients with coronary disease (SQ30217 - 16/20, TI - 17/20, p = NS) and identifying abnormal vessels (SQ30217 - 19/45, TI - 21/45, p = NS). Both agents were falsely positive in 1/15 vessels. Ten vascular regions showed persistent abnormalities on resting SQ30217 scans; eight of these were distal to stenoses of at least 90% and three were also abnormal on thallium redistribution images. Hepatic uptake of SQ30217 obscured inferoapical segments in some views in 14/20 patients but did not interfere with abnormal vessel identification.