MULTIPLE AMPHETAMINE INJECTIONS REDUCE THE RELEASE OF ASCORBIC-ACID IN THE NEOSTRIATUM OF THE RAT
MULTIPLE AMPHETAMINE INJECTIONS REDUCE THE RELEASE OF ASCORBIC-ACID IN THE NEOSTRIATUM OF THE RAT
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DOI：
10.1016/0006-8993(86)90458-0
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发表时间：
1986-01-08
期刊：
影响因子：
2.9
通讯作者：
REBEC, GV
中科院分区：
文献类型：
--
作者：
KAMATA, K;WILSON, RL;REBEC, GV
伏安信号记录双边与未经修饰或电化学修饰的碳纤维电极在大鼠的新纹状体，持续单方面消耗多巴胺预处理与6-羟基多巴胺。在两个半球，简单的每日注射D-苯丙胺（5.0毫克/公斤或稳定增加剂量开始与6.0毫克/公斤）连续6天显着降低了由挑战注射2.5毫克/公斤D-苯丙胺产生的氧化电流的上升相比，从生理盐水处理的控制。伏安扫描表明，氧化产物具有抗坏血酸的电化学特性。因此，看来多次注射安非他明减少了新纹状体中抗坏血酸的释放，并且这种作用不依赖于多巴胺能神经元的完整性。
Voltammetric signals were recorded bilaterally with unmodified or electrochemically-modified carbon-fiber electrodes in the neostriatum of rats that sustained a unilateral depletion of dopamine by pretreatment with 6-hydroxydopamine. In both hemispheres, simple daily injections of D-amphetamine (5.0 mg/kg or steadily increasing doses beginning with 6.0 mg/kg) for 6 consecutive days significantly reduced the rise in oxidation current produced by a challenge injection of 2.5 mg/kg D-amphetamine compared to the response obtained from saline-treated controls. Voltammetric scans indicated that the oxidized substance shared the electrochemical characteristics of asorbic acid. It appears, therefore, that multiple amphetamine injections reduce the release of ascorbic acid in the neostriatum and that this effect does not depend on the integrity of dopaminergic neurons.