Dynamic Contrast-Enhanced Texture Analysis of the Liver Initial Assessment in Colorectal Cancer
Dynamic Contrast-Enhanced Texture Analysis of the Liver Initial Assessment in Colorectal Cancer
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DOI：
10.1097/rli.0b013e3181f8e8a2
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发表时间：
2011-03-01
影响因子：
6.7
通讯作者：
Miles, Kenneth
中科院分区：
文献类型：
--
作者：
Ganeshan, Balaji;Burnand, Katherine;Miles, Kenneth
目的：为了进行初步评估的潜在效用的动态对比增强纹理分析（DCE-TA）的肝脏在结直肠癌patients with colorectal cancer.Materials and Methods：TA包括测量的平均灰度强度，熵，和均匀性，并没有选择性的规模过滤使用带通滤波器，突出不同的空间频率反映细，中，粗纹理。初始体模研究评估了每个纹理限定器对计算机断层扫描（CT）采集参数的灵敏度。纹理分析的DCE-CT系列从27例结直肠癌患者具有明显正常的肝脏形态（淋巴结阴性：n = 8，淋巴结阳性：n = 19）。通过使用动力学建模来计算肝脏灌注指数后，精细，中等，和粗糙的图像filter.Results：所有的纹理质量的平均变化进行了定性和定量评估对比剂引起的肝脏纹理的变化是不太敏感的CT采集参数的变化比CT衰减测量。肝脏纹理的时间变化与增强的变化有质的不同。淋巴结阴性和淋巴结阳性患者之间至少在1个时间段内观察到肝脏增强测量值和所有纹理参数的统计学显著差异。差异最具统计学显著性，并且发生在量化为平均灰度强度（5个时间段，最小P值：0.006）的精细纹理的最大数量的时间段内，其次是量化为熵（4个时间点，最小P值：0.006）的精细纹理。两组的肝脏灌注指数无差异。结论：DCE-TA是DCE-CT的潜在有用辅助手段，值得进一步研究。
Purpose: To undertake an initial assessment of the potential utility of dynamic contrast-enhanced texture analysis (DCE-TA) of the liver in patients with colorectal cancer.Materials and Methods: TA comprised measurement of mean gray-level intensity, entropy, and uniformity with and without selective-scale filtration using a band-pass filter to highlight different spatial frequencies reflecting fine, medium, and coarse textures. An initial phantom study assessed the sensitivity of each texture qualifier to computed tomography (CT) acquisition parameters. Texture was analyzed in DCE-CT series from 27 colorectal cancer patients having apparently normal hepatic morphology (node-negative: n = 8, node-positive: n = 19). Averaged changes in hepatic texture induced by contrast material were assessed qualitatively and quantitatively by using kinetic modeling to calculate hepatic perfusion indices following fine, medium, and coarse image filtration.Results: All texture qualifiers were less sensitive to changes in CT acquisition parameters than measurement of CT attenuation. Temporal changes in hepatic texture were qualitatively different from changes in enhancement. Statistically significant differences between node-negative and node-positive patients were observed for at least 1 time period for measurements of hepatic enhancement and for all texture parameters. The differences were most statistically significant and occurred over the greatest number of time periods for fine texture quantified as mean gray-level intensity (5 time periods, minimum P value: 0.006) followed by fine texture quantified as entropy (4 time points, minimum P value: 0.006). There was no difference in hepatic perfusion indices for the 2 groups.Conclusions: DCE-TA is a potentially useful adjunct to DCE-CT warranting further investigation.