Putting on the Brakes: Cyclic AMP as a Multipronged Controller of Macrophage Function
Putting on the Brakes: Cyclic AMP as a Multipronged Controller of Macrophage Function
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DOI：
10.1126/scisignal.275pe37
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发表时间：
2009-06-16
影响因子：
7.3
通讯作者：
Peters-Golden, Marc
中科院分区：
文献类型：
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作者：
Peters-Golden, Marc
巨噬细胞通过激活各种促炎信号程序来协调组织中的先天免疫反应。预防这种程序过度激活引起的炎症性疾病状态的一个关键机制是通过连接某些鸟嘌呤核苷酸结合蛋白(G蛋白)偶联受体(GPCRs)来产生第二信使环腺苷单磷酸(CAMP)。这种环核苷酸对巨噬细胞各种炎症功能的多效性作用是由不同的分子机制介导的，包括组装不同的多蛋白复合体。更好地了解巨噬细胞内cAMP信号和促炎通路之间的串扰可能为改进免疫调节策略提供基础。
Macrophages orchestrate innate immune responses in tissues by activating various proinflammatory signaling programs. A key mechanism for preventing inflammatory disease states that result from excessive activation of such programs is the generation of the second messenger cyclic adenosine monophosphate (cAMP) by ligation of certain guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs). The pleiotropic actions of this cyclic nucleotide on various inflammatory functions of macrophages are mediated by diverse molecular mechanisms, including the assembly of distinct multiprotein complexes. A better understanding of crosstalk between cAMP signaling and proinflammatory pathways in macrophages may provide a basis for improved immunomodulatory strategies.