Viral immunity. Transkingdom control of viral infection and immunity in the mammalian intestine.
Viral immunity. Transkingdom control of viral infection and immunity in the mammalian intestine.
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DOI：
10.1126/science.aad5872
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发表时间：
2016-01-15
期刊：
影响因子：
--
通讯作者：
Virgin HW
中科院分区：
文献类型：
--
作者：
Pfeiffer JK;Virgin HW
感染肠道的病毒包括人类主要病原体(逆转录病毒、诺如病毒、轮状病毒、星状病毒、微小核糖核酸病毒、腺病毒、疱疹病毒)，构成了全球主要的公共卫生问题。这些病毒病原体是居住在肠道的一个大型复杂病毒群落的成员，称为肠道病毒群。肠道病毒与寄主和肠道中的其他微生物成分有密切的功能和遗传关系，如细菌微生物区系、与其相关的噬菌体、蠕虫和真菌，它们共同构成微生物群。新出现的数据表明，肠道病毒通过一系列被称为跨王国相互作用的过程来调节这些其他微生物，并反过来受到这些微生物的调节。这代表了对病毒感染的肠道免疫模式的变化。在这里，我们回顾了该领域的最新进展，并提出了将这一重要领域概念化的新方法。
Viruses that infect the intestine include major human pathogens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) constituting a major public health problem worldwide. These viral pathogens are members of a large, complex viral community inhabiting the intestine termed the enteric virome. Enteric viruses have intimate functional and genetic relationships with both the host and other microbial constituents that inhabit the intestine, like the bacterial microbiota, their associated phages, helminthes and fungi which together constitute the microbiome. Emerging data indicate that enteric viruses regulate, and are in turn regulated by, these other microbes through a series of processes termed transkingdom interactions. This represents a changing paradigm in intestinal immunity to viral infection. Here we review recent advances in the field and propose new ways in which to conceptualize this important area.