Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization
Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization
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DOI：
10.1021/ol062288o
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发表时间：
2006-12-21
期刊：
影响因子：
5.2
通讯作者：
Zhao, Kang
中科院分区：
文献类型：
--
作者：
Du, Yunfei;Liu, Renhe;Zhao, Kang
通过苯基碘双三氟乙酸盐（PIFA）的分子内环化反应，合成了一系列N-芳基化和N-烷基化吲哚衍生物。这种新的方法允许通过在最后一个合成步骤中将侧链上的N-原子连接到苯环上来构建吲哚骨架。通过该方法还可以得到其它新的吡咯稠合芳族化合物。
A variety of N- arylated and N- alkylated indole derivatives were synthesized by way of a phenyliodine bis( trifluoroacetate) ( PIFA)- mediated intramolecular cyclization. This novel method allows for the construction of an indole skeleton by joining the N- atom on the side chain to the benzene ring at the last synthetic step. Other novel pyrrole- fused aromatic compounds can also be achieved by this method.