Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives.
Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives.
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DOI：
10.1039/c1ob06630g
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发表时间：
2012-01
影响因子：
3.2
通讯作者：
Kazuo Tanaka;M. Murakami;Jonghwan Jeon;Y. Chujo
中科院分区：
文献类型：
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作者：
Kazuo Tanaka;M. Murakami;Jonghwan Jeon;Y. Chujo
我们报道了树枝状大分子中的多面体低聚倍半硅氧烷（POSS）核可以通过1，8-萘啶和鸟苷核苷酸之间的氢键增强分子识别的亲和力。研究了萘啶配体与一系列鸟苷核苷酸的络合作用，结果表明，POSS核心通过氢键在络合物的稳定中起重要作用。最后，我们证明，1，8-萘啶配体可以选择性地识别鸟苷三磷酸通过协助POSS核心树枝状聚合物。
We report that a polyhedral oligomeric silsesquioxane (POSS) core in a dendrimer can enhance the affinity of the molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides. The complexation of the naphthyridine ligands with a series of guanosine nucleotides was investigated, and it is shown that the POSS core should play a significant role in the stabilization of the complexes via hydrogen bonds. Finally, we demonstrate that the 1,8-naphthyridine ligand can selectively recognize guanosine triphosphate by assisting with the POSS-core dendrimer.