Cryotherapy for breast cancer: a feasibility study without excision.
Cryotherapy for breast cancer: a feasibility study without excision.
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DOI：
10.1016/j.jvir.2009.06.029
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发表时间：
2009-10
影响因子：
2.9
通讯作者：
Bouwman, David
中科院分区：
文献类型：
--
作者：
Littrup, Peter J.;Jallad, Bassel;Chandiwala-Mody, Priti;D'Agostini, Monica;Adam, Barbara A.;Bouwman, David
评估经皮多探头乳腺冷冻消融术（BC）治疗BC后仍留在原位的各种癌症的可行性。在进行乳腺磁共振（MR）成像和全面咨询后，患者在知情同意后接受了BC。本研究已获得机构审查委员会的批准。在12次BC治疗中，11例拒绝手术的患者接受了22个乳腺癌病灶（I-IV期）的治疗，使用了多个2.4 mm冷冻探针。5名患者复发，6名患者新诊断。仅使用局部麻醉，6名患者接受超声（US）引导治疗，5名患者接受计算机断层扫描（CT）和US引导治疗。使用盐水注射和加温袋保护皮肤。手术成功定义为所有肿瘤边缘外1 cm可见冰。在BC后长达72个月的MR成像和/或临床随访可用。US对小肿瘤产生足够的冰可视化，而CT有助于确认整体冰范围。平均治疗前乳腺肿瘤直径为1.7 cm ± 1.2 cm（范围：0.5-5.8 cm），平均3.1个冷冻探针产生了100%的手术成功率，平均冰直径为5.1 cm ± 2.2 cm（范围：2.0-10.0 cm）。未发现明显并发症、牵开或瘢痕。CT检查后即刻和随访时，冷冻消融部位边缘的活检结果均为阴性。在平均18个月的影像学随访中没有发现局部复发。结合全面的消融前和消融后MR成像，CT/US引导下多探头BC安全地实现了超出肿瘤边缘1 cm的可见冰，具有最小的不适感、良好的美容效果，并且没有短期局部肿瘤复发。
To assess the feasibility of percutaneous multiprobe breast cryoablation (BC) for diverse presentations of cancers that remained in situ after BC. After breast magnetic resonance (MR) imaging and thorough consultation, patients underwent BC after giving informed consent. This study was approved by the institutional review board. In 12 BC sessions, 22 breast cancer foci (stages I–IV) were treated in 11 patients who refused surgery by using multiple 2.4-mm cryoprobes. Five patients had recurrent disease and six had new diagnoses. With use of only local anesthesia, six patients were treated with ultrasonographic (US) guidance and five were treated with both computed tomographic (CT) and US guidance. Saline injections and warming bags were used to protect the skin. Procedure success was defined as 1 cm visible ice beyond all tumor margins. MR imaging and/or clinical follow-up were available for up to 72 months after BC. US produced sufficient ice visualization for small tumors, whereas CT helped confirm overall ice extent. The mean pretreatment breast tumor diameter was 1.7 cm ± 1.2 (range, 0.5–5.8 cm), and an average of 3.1 cryoprobes produced 100% procedural success with mean ice diameters of 5.1 cm ± 2.2 (range, 2.0–10.0 cm). No significant complications, retraction, or scarring were noted. Biopsies at the margins of the cryoablation site immediately after BC and at follow-up were all negative. No local recurrences have been noted at an average imaging follow-up of 18 months. In conjunction with thorough pre- and postablation MR imaging, CT/US-guided multiprobe BC safely achieved 1 cm visible ice beyond tumor margins with minimal discomfort, good cosmesis, and no short-term local tumor recurrences.
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影响因子：
6.7
作者：
Pfleiderer, SOR;Marx, C;Kaiser, WA
通讯作者：
Kaiser, WA
影响因子：
4
作者：
Conlin, Alison K.;Seidman, Andrew D.
通讯作者：
Seidman, Andrew D.
影响因子：
3.7
作者：
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通讯作者：
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DOI：
10.1016/j.jvir.2006.12.007
发表时间：
2007-03-01
影响因子：
2.9
作者：
Littrup, Peter J.;Ahmed, Abraham;Heilbrun, Lance K.
通讯作者：
Heilbrun, Lance K.
影响因子：
3.1
作者：
Ozdemir, Aysegul;Voyvoda, Nuray Kadioglu;Yamac, Deniz
通讯作者：
Yamac, Deniz