Vitamin D receptor gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
Vitamin D receptor gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
复制标题
维生素 D 受体基因多态性与腰椎间盘退变：系统评价和荟萃分析
DOI：
10.1007/s00586-016-4771-2
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发表时间：
2017-01-01
影响因子：
2.8
通讯作者：
Wei, Qingjun
中科院分区：
文献类型：
--
作者：
Jiang, Hua;Qin, Zhilin;Wei, Qingjun
目的探讨维生素D受体(VDR)基因多态性与腰椎间盘退行性变(LDD)易感性的关系。从每项研究中提取等位基因/基因型频率。我们计算了合并优势比(OR)和95%可信区间(CI)，以评估VDR基因多态与LDD风险之间的关联强度。采用Revman 5.31软件进行统计分析。结果共纳入23项病例对照研究，其中病例组1835例，对照组1923例。对于VDR基因Taqi(Rs731236)、FokI(Rs2228570)和Apai(Rs7975232)的多态，最终分别有9个研究、7个研究和5个研究进入Meta分析。没有证据表明VDR基因(TaqI、FokI、APAi)与腰椎间盘突出症有显著关联(TaqI等位基因比较，OR=0.07，95%CI 0.81~1.40，p=0.64；FokI等位基因比较，OR=61.23，95%CI 0.83~1.82，p=0.31；APAi等位基因比较，OR=0.79，95%CI 0.55~1.14，p=0.20)。按种族和研究设计进行分层分析，未发现高加索人群和亚洲人群以及所有遗传模式下的基于人群的研究和基于医院的研究存在显著关联。结论VDR基因TaqI、FokI和Apai基因多态性与LDD的易感性无关。需要大规模和精心设计的国际研究来进一步分析这一领域。
PurposeTo examine the association between Vitamin D receptor (VDR) gene polymorphisms and lumbar disc degeneration (LDD) predisposition.MethodsA comprehensive literature search was conducted to identify all the relevant studies. The allele/genotype frequencies were extracted from each study. We calculated the pooled odds ratios (ORs) and 95 % confidence intervals (CI) to assess the strength of the association between the VDR gene polymorphisms and LDD risk. Statistical analysis was performed using RevMan 5.31 software.ResultsA total of 23 case–control studies (1835 cases and 1923 controls) were included in this systematic review. For the TaqI (rs731236), FokI (rs2228570) and ApaI (rs7975232) polymorphisms of VDR gene, nine studies, seven studies, and five studies, were eventually included in the meta-analysis, respectively. There was no evidence that the VDR gene polymorphisms (TaqI, FokI, ApaI) had significant associations with LDD risk.(for TaqI allelic comparison, OR = 1.07, 95 % CI 0.81–1.40,p= 0.64; for FokI allelic comparison, OR = 1.23, 95 % CI 0.83–1.82,p= 0.31; for ApaI allelic comparison, OR = 0.79, 95 % CI 0.55–1.14,p= 0.20). For stratified analyses by ethnicity and study design, no significant associations were found in Caucasian population and Asian population, as well as the population-based studies and hospital-based studies under all genetic models.ConclusionsTaqI, FokI, and ApaI polymorphisms of VDR gene were not significantly associated with the predisposition of LDD. Large-scale and well-designed international studies are needed to further analyze this field.