Genetics of coffee consumption and its stability
Genetics of coffee consumption and its stability
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DOI：
10.1111/j.1360-0443.2008.02375.x
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发表时间：
2008-12-01
期刊：
影响因子：
6
通讯作者：
Silventoinen, Karri
中科院分区：
文献类型：
--
作者：
Laitala, Venla S.;Kaprio, Jaakko;Silventoinen, Karri
咖啡是一种非常受欢迎的饮料，与几种疾病的发病机制以及烟草和酒精的使用有关。考虑到全球消费量，咖啡对个人健康和公共健康有重大影响。遗传因素对个体间差异的作用及其在咖啡使用中的稳定性尚不清楚，我们分析了咖啡消费量的遗传性及其在芬兰双胞胎中的稳定性，在1975年和1981年，我们向1958年之前出生的所有芬兰同性双胞胎发送了一份关于咖啡消费量的邮寄问卷。1975年，从10716对完全双胞胎中获得了应答（3409对单卵双胞胎和7307对双卵双胞胎），其中8124对在1981年也有应答。数据进行了分析，使用经典的双胞胎模型的基础上线性结构equations.Additive遗传和独特的环境因素影响咖啡饮用，而共享的环境因素没有显示出任何效果。根据年龄和性别调整后，咖啡消费量的遗传力估计为1975年的0.56和1981年的0.45。咖啡消费量在这两个时间点之间显示出中度相关性（男性r = 0.58，女性r = 0.55）。影响咖啡消费的遗传因素是稳定的：男性和女性的加性遗传相关性分别为0.84和0.83，而独特的环境相关性是中等的（0.45和0.36）。加性遗传因素在年轻人中的贡献最大。咖啡消费受到加性遗传和独特环境因素的影响，每一个因素都起着几乎同等重要的作用。咖啡消费的长期稳定性主要受到一系列稳定的加性遗传因素的影响。
Coffee is a highly popular drink associated with the pathogenesis of several diseases and the use of tobacco and alcohol. Considering the worldwide consumption, coffee has a substantial effect on individual wellbeing and public health. The role of genetic factors contributing to interindividual differences and their stability in coffee use is not well known.We analysed the heritability of coffee consumption and its stability in a large population-based sample of Finnish twins.In 1975 and 1981 a postal questionnaire on coffee consumption was sent to all Finnish same-sex twin pairs born before 1958. Responses were obtained from 10 716 complete twin pairs in 1975 (3409 monozygotic and 7307 dizygotic), of whom 8124 also responded in 1981. The data were analysed using classical twin modelling based on linear structural equations.Additive genetic and unique environmental factors affected coffee drinking, whereas shared environmental factors did not show any effect. Heritability of coffee consumption, adjusted for age and sex, was estimated as 0.56 in 1975 and 0.45 in 1981. Coffee consumption showed a moderate correlation between these two time-points (r = 0.58 in men and 0.55 in women). Genetic factors affecting coffee consumption were stable: additive genetic correlations were 0.84 in men and 0.83 in women, whereas unique environmental correlations were moderate (0.45 and 0.36). Additive genetic factors had the highest contribution in young adults.Coffee consumption is affected by both additive genetic and unique environmental factors, each of which plays an almost equally important role. The long-term stability of coffee consumption is affected mainly by a stable set of additive genetic factors.