Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries: Prospective Evaluation of Healthy Subjects
Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries: Prospective Evaluation of Healthy Subjects
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DOI：
10.2967/jnumed.115.159798
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发表时间：
2015-10-01
影响因子：
9.3
通讯作者：
Hoilund-Carlsen, Poul F.
中科院分区：
文献类型：
--
作者：
Blomberg, Bjorn Alexander;Thomassen, Anders;Hoilund-Carlsen, Poul F.
氟-18-氟化钠（F-18-NaF）PET/CT成像是评估动脉粥样硬化的一种有前途的成像技术，但由于缺乏有效的量化方案而受到阻碍。个人特征和技术因素都可能影响动脉F-18-NaF摄取的定量。本研究调查了血液活性、肾功能、注射剂量、循环时间和PET/CT系统是否影响动脉F-18-NaF摄取的定量。方法：89例健康受试者前瞻性地进行了F-18-NaF PET/CT成像检查。通过计算最大F-18-NaF活性（NaFmax）、最大/平均目标-背景比（TBRmax/平均值）和最大血液减去F-18-NaF活性（bsNaFmax），在升主动脉、主动脉弓、胸降主动脉和冠状动脉水平定量动脉F-18-NaF摄取。多变量线性回归评估了个人特征和技术因素对动脉F-18-NaF摄取定量的影响。结果如下：NaFmax和TBRmax/mean依赖于血液活性（分别为β = 0.34 ~ 0.44，P < 0.001和β = -0.68 ~-0.58，P < 0.001）和PET/CT系统（分别为β = -0.80 ~-0.53，P < 0.001和β = -0.80 ~-0.23，P < 0.031）。bsNaFmax依赖于PET/CT系统（β = -0.91 ~-0.57，P < 0.001），而不依赖于血液活性。在升主动脉、主动脉弓、降胸主动脉和冠状动脉水平观察到这一发现。除血液活性和PET/CT系统外，注射剂量影响动脉F-18-NaF摄取的定量，而肾功能和循环时间不影响。结论：对89名健康受试者的前瞻性评价表明，动脉F-18-NaF摄取的定量受血液活性、注射剂量和PET/CT系统的影响。因此，应考虑血液活性、注射剂量和PET/CT系统，以准确估计动脉F-18-NaF摄取。
Sodium F-18-fluoride (F-18-NaF) PET/CT imaging is a promising imaging technique for the assessment of atherosclerosis but is hampered by a lack of validated quantification protocols. Both personal characteristics and technical factors can affect quantification of arterial F-18-NaF uptake. This study investigated whether blood activity, renal function, injected dose, circulating time, and PET/CT system affect quantification of arterial F-18-NaF uptake. Methods: Eighty-nine healthy subjects were prospectively examined by F-18-NaF PET/CT imaging. Arterial F-18-NaF uptake was quantified at the level of the ascending aorta, aortic arch, descending thoracic aorta, and coronary arteries by calculating the maximum F-18-NaF activity (NaFmax), the maximum/mean target-to-background ratio (TBRmax/mean), and the maximum blood-subtracted F-18-NaF activity (bsNaFmax). Multivariable linear regression assessed the effect of personal characteristics and technical factors on quantification of arterial F-18-NaF uptake. Results: NaFmax and TBRmax/mean were dependent on blood activity (beta = 0.34 to 0.44, P < 0.001, and beta = -0.68 to -0.58, P < 0.001, respectively) and PET/CT system (beta = -0.80 to -0.53, P < 0.001, and beta = -0.80 to -0.23, P < 0.031, respectively). bsNaFmax depended on PET/CT system (beta = -0.91 to -0.57, P < 0.001) but not blood activity. This finding was observed at the level of the ascending aorta, aortic arch, descending thoracic aorta, and the coronary arteries. In addition to blood activity and PET/CT system, injected dose affected quantification of arterial F-18-NaF uptake, whereas renal function and circulating time did not. Conclusion: The prospective evaluation of 89 healthy subjects demonstrated that quantification of arterial F-18-NaF uptake is affected by blood activity, injected dose, and PET/CT system. Therefore, blood activity, injected dose, and PET/CT system should be considered to generate accurate estimates of arterial F-18-NaF uptake.