Myotome formation: A multistage process
Myotome formation: A multistage process
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DOI：
10.1007/s004410051277
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发表时间：
1999-04-01
影响因子：
3.6
通讯作者：
Kahane, N
中科院分区：
文献类型：
--
作者：
Kalcheim, C;Cinnamon, Y;Kahane, N
身体的上轴肌肉相对于轴向结构位于背内侧位置，附着于脊柱并与脊柱的姿势和运动的维持有关。轴外肌肉组织源自肌节，这是一种短暂的胚胎结构，其形成始于上皮体节阶段，并在上皮肌节完全解离后完成。最近的结果表明，肌组发育是一个多阶段过程，其特征是肌肉祖细胞的连续波的添加。第一个波沿上皮体节的内侧部分起源，并产生初级肌节结构，第二个波从上皮肌节的头端和尾端唇以及背内侧唇产生，通过头端和尾端边缘间接做出贡献，第三波由有丝分裂活跃的常驻祖细胞组成，导致肌节块的显着生长和 其过渡到轴外肌。在这篇综述中，我们讨论了起源、迁移以及已知的细胞和分子特征，这些特征描述了定植于肌节的每一波祖细胞的特征。
The epaxial muscles of the body are localized in a dorsomedial position with respect to the axial structures, attach to the vertebral column and are concerned with maintenance of posture and movements of the vertebral column. The epaxial musculature derives from the myotome, a transient embryonic structure whose formation is initiated at the epithelial somite stage and is accomplished following complete dissociation of the epithelial dermomyotome. Recent results suggest that myotome development is a multistage process, characterized by addition of sequential waves of muscle progenitors. A first wave originates along the medial part of the epithelial somite and gives rise to a primary myotomal structure, a second wave arises from the rostral and caudal lips of the epithelial dermomyotome and from the dorsomedial lip, which contributes indirectly through the rostral and caudal edges, and a third wave which is composed of mitotically active resident progenitors accounts for significant growth of the myotomal mass and for its transition into epaxial muscle. In this review we discuss the origin, migration and known cellular and molecular features that characterize each wave of progenitors that colonize the myotome.