INCIDENCE OF DISSEMINATED GONOCOCCAL-INFECTION CORRELATED WITH THE PRESENCE OF AHU AUXOTYPE OF NEISSERIA-GONORRHOEAE IN A COMMUNITY
INCIDENCE OF DISSEMINATED GONOCOCCAL-INFECTION CORRELATED WITH THE PRESENCE OF AHU AUXOTYPE OF NEISSERIA-GONORRHOEAE IN A COMMUNITY
复制标题
DOI：
10.1097/00007435-198404000-00003
复制
发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
HALEY, JV
中科院分区：
文献类型：
--
作者：
NOBLE, RC;REYES, RR;HALEY, JV
在美国肯塔基州列克星顿-费耶特县9年以上的社区中，播散性淋球菌感染的发生率与AHU[精氨酸、次黄嘌呤、尿嘧啶]缺位型淋球菌的存在之间存在显著的流行病学关联。1982. 在此期间，在性病诊所和医院急诊室收集了社区患者的淋球菌分离物。1978年以后，DGI住院患者的发生率显著下降。DGI发病率最高的年份为1977年，为429例/10万例无并发症淋病；该年AHU型淋球菌分离株的发病率为26.3%。1980年，当DGI的发病率下降到58例/10万例无并发症淋病时，这种异型仅占淋球菌分离株的4.6%。按年度对社区中DGI与AHU异型淋球菌的发病率进行排序，发现两者之间存在显著相关性（P < 0.001）。因此，医院DGI患者的发病率反映了社区中AHU型淋球菌的存在。
A significant epidemiologic association was noted between the incidence of disseminated gonococcal infection and the presence of gonococci of the AHU [arginine, hypoxanthine, uracil] auxotype in the community [Lexington-Fayette County, Kentucky, USA] over 9 yr. Patients (39) with DGI were identified from hospital records of Jan. 1974-Dec. 1982. During this interval, gonococcal isolates from patients in the community were collected at a venereal disease clinic and a hospital emergency room. The incidence of patients hospitalized for DGI dropped significantly after 1978. The year of highest incidence of DGI was 1977, when there were 429 cases of DGI/100,000 cases of uncomplicated gonorrhea; the incidence of gonococcal isolates of the AHU auxotype in that year was 26.3%. This auxotype accounted for only 4.6% of gonococcal isolates in 1980, when the incidence of DGI had decreased to 58 cases/100,000 cases of uncomplicated gonorrhea. When DGI and gonococci of the AHU auxotype from the community were ranked for incidence by year, a significant correlation between the 2 was found (P < 0.001). Thus, the incidence of patients with DGI in the hospital reflected the presence of gonococci of the AHU auxotype in the community.