Neuromodulation of hypoglossal motoneurons: cellular and developmental mechanisms
Neuromodulation of hypoglossal motoneurons: cellular and developmental mechanisms
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DOI：
10.1016/s0034-5687(97)00079-0
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发表时间：
1997-11-01
期刊：
影响因子：
--
通讯作者：
Berger, AJ
中科院分区：
文献类型：
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作者：
Bayliss, DA;Viana, F;Berger, AJ
尾侧脑干的舌下神经运动神经元（HMs）有一个与呼吸相关的活动模式，并有助于控制上气道阻力。在这篇综述中，我们主要集中在神经递质，以提高HM兴奋性的信号转导机制。我们尤其认为：（1）促甲状腺素释放激素（TRH）、5-羟色胺（5-HT）、去甲肾上腺素（NE）等多种递质引起的膜去极化，（2）5-HT对钙依赖性锋电位后超极化（AHP）的抑制及其对放电行为的影响。这些不同的神经递质的影响HM行为的潜在功能后果进行了讨论。此外，我们描述了出生后的变化，发射机的影响，并建议潜在的细胞机制来解释这些发展变化。讨论的大部分数据来自于新生大鼠和成年大鼠的体外电生理记录。(C)1997年Elsevier Science B.V.
Hypoglossal motoneurons (HMs) in the caudal brainstem have a respiratory-related activity pattern and contribute to control of upper airway resistance. In this review, we focus primarily on signalling mechanisms utilized by neurotransmitters to enhance HM excitability. In particular, we consider: (1) the membrane depolarization induced by a number of different putative transmitters [thyrotropin-releasing hormone (TRH), serotonin (5-HT), norepinephrine (NE)]; and (2) the inhibition of a calcium-dependent spike afterhyperpolarization (AHP) by 5-HT and its effect on firing behavior. Potential functional consequences on HM behavior of these different neurotransmitter effects is discussed. In addition, we describe postnatal changes in transmitter effects and suggest potential cellular mechanisms to explain those developmental changes. Most of the data discussed are derived from in vitro electrophysiological recordings performed in preparations from neonatal and adult rats. (C) 1997 Elsevier Science B.V.