Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine
Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine
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DOI：
10.1111/j.1369-1600.2008.00125.x
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发表时间：
2008-09-01
影响因子：
3.4
通讯作者：
Jerlhag, Elisabet
中科院分区：
文献类型：
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作者：
Jerlhag, Elisabet
已知胃饥饿素，优选通过下丘脑回路，在控制能量平衡、体重稳态和食欲中起作用。此外，最近发现，将ghrelin注射到中脑边缘多巴胺（DA）系统的关键结构中增加啮齿动物的食物摄入，并诱导小鼠的运动刺激以及脑内DA溢出。因此，中枢给药的胃饥饿素激活中脑边缘DA系统。然而，ghrelin主要在外周组织中产生和分泌。因此，本系列的实验进行了调查外周注射生长激素释放肽对中脑边缘DA系统的活动，因此，相关的行为的影响。腹腔注射ghrelin（0.33mg/kg）可引起小鼠自发性兴奋、条件性位置偏爱和脑DA溢出。总之，外周产生的ghrelin，例如在胃中，可以激活中脑边缘DA系统。这表明，餐前血浆胃饥饿素的升高可能通过该系统增加了对有动机行为（如寻找食物）的激励值。
Ghrelin, preferably via hypothalamic circuits, is known to play a role in the control of energy balance, body weight homeostasis and appetite. In addition, it has recently been found that ghrelin injection into key structures of the mesolimbic dopamine (DA) system increases food intake in rodents and induces locomotor stimulation as well as accumbal DA overflow in mice. Thus, centrally administered ghrelin activates the mesolimbic DA system. However, ghrelin is mainly produced in and secreted from peripheral tissues. The present series of experiments were therefore undertaken to investigate the effects of peripherally injected ghrelin on mesolimbic DA system activity and, herewith, associated behaviours. It was found that intraperitoneal administration of ghrelin (0.33 mg/kg) induces locomotor stimulation, conditioned place preference and accumbal DA-overflow in mice. In conclusion, peripherally produced ghrelin, e.g. in the stomach, may activate the mesolimbic DA system. This suggests that the pre-prandial rise in plasma ghrelin may, via this system, increase the incentive value for motivated behaviours such as food seeking.