Insulin-like growth factors and their binding proteins: biological actions.
Insulin-like growth factors and their binding proteins: biological actions.
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DOI：
10.1210/edrv-16-1-3
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发表时间：
1995-02
影响因子：
20.3
通讯作者：
John I. Jones;D. Clemmons
中科院分区：
文献类型：
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作者：
John I. Jones;D. Clemmons
胰岛素样生长因子是基于其刺激软骨磺化和替代生长激素“磺化因子活性”的能力而被发现的，这是通过体内试验在体外测试系统中确定的(1)。这一发现的生物学意义很快扩展到软骨磺化的研究之外，包括刺激DNA合成(2)、蛋白聚糖合成(3)、糖胺聚糖合成(4)和蛋白质合成(5)。这些研究大多使用组织制剂，如分离隔膜、软骨或附睾脂肪垫来研究生物活性。由于认识到其广泛的多型作用，在20世纪70年代初，硫酸化因子被重新命名为生长激素（促生长激素作用的中介因子），并与血小板衍生生长因子、成纤维细胞生长因子和表皮生长因子一起被纳入新兴的广谱生长因子分类(6)。在…的生物作用期间…
I. Introduction THE insulin-like growth factors were discovered on the basis of their ability to stimulate cartilage sulfation and to replace the “sulfation factor activity” of GH, as determined using an in vivo assay, in an in vitro test system (1). The biological significance of this finding was quickly expanded beyond the study of cartilage sulfation to include stimulation of DNA synthesis (2), proteoglycan synthesis (3), glycosaminoglycan synthesis (4), and protein synthesis (5). Most of these studies used tissue preparations such as isolated diaphragm, cartilage, or epididymal fat pads to study biologicalactivity. In recognition of its generalized pleiotypic actions, in the early 1970's sulfation factor was renamed somatomedin (mediator of the effects of somatotropin) and was included in the emerging classification of broad spectrum growth factors along with platelet derived growth factor, fibroblast growth factor, and epidermal growth factor (6). During the period in which the biological actions of ...