Multiple Wearable Sensors in Parkinson and Huntington Disease Individuals: A Pilot Study in Clinic and at Home.
Multiple Wearable Sensors in Parkinson and Huntington Disease Individuals: A Pilot Study in Clinic and at Home.
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DOI：
10.1159/000479018
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发表时间：
2017-09-01
影响因子：
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通讯作者：
Sharma, Gaurav
中科院分区：
文献类型：
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作者：
Adams, Jamie L;Dinesh, Karthik;Sharma, Gaurav
背景：临床医生评分和患者报告的结果是评估帕金森病和亨廷顿病运动症状的主要手段。然而，这些评估是主观的，通常仅限于偶尔的面对面访问。可穿戴传感器可以客观和持续地测量运动特征，在临床研究和护理中可能有价值。方法：我们招募了患有帕金森病、亨廷顿病和前驱亨廷顿病的参与者(携带遗传标记但尚未表现出疾病症状的人)，并将5个基于加速度计的传感器戴在他们的胸部和四肢上，用于标准化的临床评估和在家2天。该研究的目的是评估可穿戴传感器的可行性，确定参与者的活动(躺、坐、站、走)，并调查参与者的体验。结果：56名个体(帕金森病16例，亨廷顿病15例，前驱亨廷顿病5例，对照组20例)进入研究。在所调度的传感器中，99.3%(278/280)获得了数据。平均而言，亨廷顿病患者的卧床时间占总时间的50%以上，大大高于先兆亨廷顿病患者(33%，p=0.003)、帕金森病患者(38%，p=0.003)和对照组(34%；p<；0.001)。大多数参与者(86%)“愿意”或“非常愿意”再次佩戴传感器。结论：在运动障碍患者中，在临床和家庭中使用可穿戴传感器是可行和受欢迎的。这些传感器可以识别有运动障碍的人和没有运动障碍的人之间在活动特征上的统计上的显著差异。此外，持续、客观的监测可以揭示临床上没有观察到的疾病特征。
BACKGROUND: Clinician rating scales and patient-reported outcomes are the principal means of assessing motor symptoms in Parkinson disease and Huntington disease. However, these assessments are subjective and generally limited to episodic in-person visits. Wearable sensors can objectively and continuously measure motor features and could be valuable in clinical research and care.METHODS: We recruited participants with Parkinson disease, Huntington disease, and prodromal Huntington disease (individuals who carry the genetic marker but do not yet exhibit symptoms of the disease), and controls to wear 5 accelerometer-based sensors on their chest and limbs for standardized in-clinic assessments and for 2 days at home. The study's aims were to assess the feasibility of use of wearable sensors, to determine the activity (lying, sitting, standing, walking) of participants, and to survey participants on their experience.RESULTS: Fifty-six individuals (16 with Parkinson disease, 15 with Huntington disease, 5 with prodromal Huntington disease, and 20 controls) were enrolled in the study. Data were successfully obtained from 99.3% (278/280) of sensors dispatched. On average, individuals with Huntington disease spent over 50% of the total time lying down, substantially more than individuals with prodromal Huntington disease (33%, p = 0.003), Parkinson disease (38%, p = 0.01), and controls (34%; p < 0.001). Most (86%) participants were "willing" or "very willing" to wear the sensors again.CONCLUSIONS: Among individuals with movement disorders, the use of wearable sensors in clinic and at home was feasible and well-received. These sensors can identify statistically significant differences in activity profiles between individuals with movement disorders and those without. In addition, continuous, objective monitoring can reveal disease characteristics not observed in clinic.