3D R2* mapping of the placenta during early gestation using free-breathing multiecho stack-of-radial MRI at 3T
3D R2* mapping of the placenta during early gestation using free-breathing multiecho stack-of-radial MRI at 3T
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DOI：
10.1002/jmri.26203
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发表时间：
2019-01-01
影响因子：
4.4
通讯作者：
Wu, Holden H.
中科院分区：
文献类型：
--
作者：
Armstrong, Tess;Liu, Dapeng;Wu, Holden H.
背景多回波梯度回波笛卡尔MRI通过定量R-2* 来表征胎盘氧合。以前的研究是在1.5T下进行的，在孕龄后期（GA）使用屏气2D成像。目的评价自由呼吸（FB）3D多回波梯度回波径向叠加技术（径向）在3 T下进行胎盘R-2* 标测的准确性和可重复性，并报告早期GA期间的胎盘R-2*。研究类型前瞻性。30例正常妊娠受试者和3例缺血性胎盘疾病（IPD）受试者接受了两次扫描：GA 14-18周和19-23周。场强3 T。顺序FB径向。评估进行线性相关性（一致性系数，rho（c））和Bland-Altman分析（平均差，MD），以评价体模中径向R-2* 标测准确度与笛卡尔标测准确度的比较。使用背靠背扫描之间的重复性系数（CR）表征径向R-2* 标测重复性。在每个GA范围内，测定所有受试者的R-2* 的平均值和空间变异系数（CV），并分别测定前胎盘和后胎盘。统计检验rho（c）的显著性。使用Wilcoxon符号秩和秩和检验检验平均R-2* 和CV的差异。P < 0.05被认为是有意义的。确定IPD受试者的Z评分。结果FB桡动脉显示准确（rho（c）>= 0.996; P < 0.001;| MD|
Background Multiecho gradient-echo Cartesian MRI characterizes placental oxygenation by quantifying R-2*. Previous research was performed at 1.5T using breath-held 2D imaging during later gestational age (GA). Purpose To evaluate the accuracy and repeatability of a free-breathing (FB) 3D multiecho gradient-echo stack-of-radial technique (radial) for placental R-2* mapping at 3T and report placental R-2* during early GA. Study Type Prospective. Population Thirty subjects with normal pregnancies and three subjects with ischemic placental disease (IPD) were scanned twice: between 14-18 and 19-23 weeks GA. Field Strength 3T. Sequence FB radial. Assessment Linear correlation (concordance coefficient, rho(c)) and Bland-Altman analyses (mean difference, MD) were performed to evaluate radial R-2* mapping accuracy compared to Cartesian in a phantom. Radial R-2* mapping repeatability was characterized using the coefficient of repeatability (CR) between back-to-back scans. The mean and spatial coefficient of variation (CV) of R-2* was determined for all subjects, and separately for anterior and posterior placentas, at each GA range. Statistical Tests rho(c) was tested for significance. Differences in mean R-2* and CV were tested using Wilcoxon Signed-Rank and Rank-Sum tests. P < 0.05 was considered significant. Z-scores for the IPD subjects were determined. Results FB radial demonstrated accurate (rho(c)>= 0.996; P < 0.001; |MD|