Renal function is independently associated with circulating betatrophin.
Renal function is independently associated with circulating betatrophin.
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DOI：
10.1371/journal.pone.0173197
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Bobbert T
中科院分区：
文献类型：
--
作者：
Maurer L;Schwarz F;Fischer-Rosinsky A;Schlueter N;Brachs S;Möhlig M;Pfeiffer A;Mai K;Spranger J;Bobbert T
在小鼠模型中，Betatrophin已被确定为连接肝脏与β细胞功能和脂质代谢的标志物。直到现在，betatrophin在人体内循环的调控还不完全清楚。我们分析了betatrophin水平与代谢综合征表型的关系，推测肾功能可能影响循环betatrophin水平，并解释了betatrophin的年龄依赖性变化。我们分析了参加柏林波茨坦代谢综合征研究的535个人的血液样本。在初步分析中，我们发现betatrophin水平与HbA1c （r = 0.24; p < 0.001）、空腹血糖（r = 0.20; p < 0.001）和甘油三酯（r = 0.12; p = 0.007）呈正相关。此外，betatrophin与年龄（r = 0.47, p <0.001）、收缩压（r = 0.17, p <0.001）、内膜中膜厚度（r = 0.26, p <0.001）呈正相关，与CKD-EPI eGFR （r = -0.33, p <0.001）负相关，作为肾功能的估计。值得注意的是，在多元线性回归模型中，在调整了年龄、腰围、性别、HbA1c和脂质参数后，eGFR与betatrophin仍然高度相关（β = -0.197, p< 0.001）。我们的数据表明，betatrophin的循环水平与年龄、性别、腰围、总/高密度脂蛋白胆固醇比率和肾功能有关。特别是与eGFR的关联突出了未来研究的重要性，即在分析betatrophin在人类中的作用时，将肾功能作为可能影响betatrophin调节的因素，并考虑eGFR作为潜在的混杂因素。
Betatrophin has been identified as a marker linking liver with beta cell function and lipid metabolism in murine models. Until now, the regulation of circulating betatrophin in humans is not entirely clear. We here analyzed the relation of betatrophin levels to phenotypes of the metabolic syndrome and speculated that renal function might influence circulating betatrophin levels and explain age-dependent changes of betatrophin. We analyzed blood samples from 535 individuals participating in the Metabolic Syndrome Berlin Potsdam study. In a crude analysis we found a positive correlation between betatrophin levels and HbA1c (r = 0.24; p < 0.001), fasting glucose (r = 0.20; p < 0.001) and triglycerides (r = 0.12; p = 0.007). Furthermore betatrophin was positively correlated with age (r = 0.47; p <0.001), systolic blood pressure (r = 0.17; p < 0.001), intima media thickness (r = 0.26; p < 0.001) and negatively correlated with CKD-EPI eGFR (r = -0.33; p < 0.001) as an estimate of renal function. Notably, eGFR remained highly associated with betatrophin after adjustment for age, waist circumference, gender, HbA1c and lipid parameters in a multivariate linear regression model (β = -0.197, p< 0.001). Our data suggest that circulating levels of betatrophin depend on age, gender, waist circumference, total/HDL cholesterol ratio and renal function. Especially the association to eGFR highlights the importance for future studies to address renal function as possible influence on betatrophin regulation and consider eGFR as potential confounder when analyzing the role of betatrophin in humans.