Exploring treatment preferences facilitated recruitment to randomized controlled trials.
Exploring treatment preferences facilitated recruitment to randomized controlled trials.
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DOI：
10.1016/j.jclinepi.2010.12.017
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发表时间：
2011-10
影响因子：
7.2
通讯作者：
Lane, J. Athene
中科院分区：
文献类型：
--
作者：
Mills, Nicola;Donovan, Jenny L.;Wade, Julia;Hamdy, Freddie C.;Neal, David E.;Lane, J. Athene
关键词：
探讨患者的治疗偏好在随机对照试验 (RCT) 招募过程中如何表达和合理化，以及它们如何影响参与和治疗决策。对英国局部前列腺癌治疗多中心随机对照试验中 93 名年龄 51-70 岁参与者的招募预约录音进行定性分析。招募时的治疗偏好比之前假设的更加复杂和动态。大多数参与者在预约初期就表达了对治疗的看法，从犹豫不决到形成良好的意见。当招募人员征求男性的意见并提供详细的基于证据的治疗和研究信息时，一些人选择了他们的偏好，但许多人变得不确定并对 RCT 招募持开放态度，常常接受与他们最初的“偏好”不同的治疗。对治疗偏好的讨论并没有成为招募的预期障碍，而是积极地使许多人能够表达他们的担忧并做出明智的决定，其中通常包括参与随机对照试验。探索治疗偏好并提供循证信息可以提高知情决策水平并促进随机对照试验的参与。治疗偏好应重新概念化，从招募障碍转变为有关治疗和随机对照试验参与的知情决策所必需的信息交换的组成部分。
To explore how patients' treatment preferences were expressed and justified during recruitment to a randomized controlled trial (RCT) and how they influenced participation and treatment decisions. Qualitative analysis of audio recordings of recruitment appointments with 93 participants aged 51–70 years in a UK multicenter RCT of localized prostate cancer treatments. Treatment preferences at recruitment were more complex and dynamic than previously assumed. Most participants expressed views about treatments early in appointments, ranging on a continuum from hesitant to well-formed opinions. As recruiters elicited men’s views and provided detailed evidence-based treatment and study information, some opted for their preference, but many became uncertain and open to RCT recruitment, often accepting a different treatment from their original “preference.” Discussion of treatment preferences did not act as the expected barrier to recruitment but actively enabled many to express their concerns and reach an informed decision that often included RCT participation. Exploring treatment preferences and providing evidence-based information can improve levels of informed decision making and facilitate RCT participation. Treatment preferences should be reconceptualized from a barrier to recruitment to an integral part of the information exchange necessary for informed decision making about treatments and RCT participation.
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影响因子：
5.4
作者：
Rowe, G;Lambert, N;Thomson, R
通讯作者：
Thomson, R
影响因子：
2.5
作者：
McDonald, Alison M.;Knight, Rosemary C.;Snowdon, Claire
通讯作者：
Snowdon, Claire
影响因子：
5.4
作者：
MARTEAU, TM
通讯作者：
MARTEAU, TM
DOI：
10.1136/bmj.a1864
发表时间：
2008-10-31
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Preference Collaborative Review Group
通讯作者：
Preference Collaborative Review Group
影响因子：
--
作者：
Moffett, JK;Torgerson, D;Barber, J
通讯作者：
Barber, J