Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis
Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis
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DOI：
10.1016/j.jneuroim.2011.12.007
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发表时间：
2012-02-29
影响因子：
3.3
通讯作者：
Ramanathan, Murali
中科院分区：
文献类型：
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作者：
Foster, Mathew;Zivadinov, Robert;Ramanathan, Murali
目的：探讨多发性硬化症 (MS) 患者的饮酒模式与残疾和脑损伤之间的关系。设计：本研究纳入了 423 名受试者（272 名 MS 患者，151 名健康对照），参与了 MS 临床、环境和遗传危险因素的研究。使用扩展残疾状态量表 (EDSS) 和 MS 严重程度量表 (MSSS) 评估残疾情况。使用 T2 病灶体积 (T2-LV)、T1-LV、脑实质标准化体积 (NBV)、灰质 (NGMV) 和侧脑室 (NLVV) 的定量 MRI 测量来评估脑损伤。与酒精消费模式相关的信息是在面对面访谈中通过标准化问卷获得的。通过回归分析评估饮酒变量与残疾和 MRI 测量结果的关联。结果：MS 患者在 MS 后不饮酒的频率 (19.4%) 高于 MS 前的频率 (p
Objective: To examine the associations of alcohol consumption patterns with disability and brain injury in multiple sclerosis (MS) patients.Design: This study included 423 subjects (272 MS patients, 151 healthy controls) participating in a study of clinical, environmental and genetic risk factors in MS. Disability was assessed with the Expanded Disability Status Scale (EDSS) and the MS Severity Scale (MSSS). Brain injury was assessed using the quantitative MRI measures of T2-lesion volume (T2-LV), T1-LV, normalized volumes of brain parenchyma (NBV), gray matter (NGMV) and lateral ventricle (NLVV). Information related to alcohol-consumption patterns was obtained with standardized questionnaire during an in-person interview. The associations of alcohol consumption variables with disability and MRI measures were assessed in regression analyses.Results: The frequency of MS patients who did not consume alcohol after MS (19.4%) was higher than the frequency before MS (p