Improvements in physical wellbeing over the first two years on antiretroviral therapy in western Kenya
Improvements in physical wellbeing over the first two years on antiretroviral therapy in western Kenya
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DOI：
10.1080/09540120903038366
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发表时间：
2010-01-01
影响因子：
1.7
通讯作者：
Simon, Jonathon L.
中科院分区：
文献类型：
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作者：
Fox, Matthew P.;Mccoy, Kelly;Simon, Jonathon L.
抗逆转录病毒治疗（ART）前六个月身体健康的改善是众所周知的，但对于长期随访却知之甚少。我们对肯尼亚西部 222 名艾滋病毒呈阳性的成年茶园工人进行了一项前瞻性队列研究，以评估他们接受抗逆转录病毒治疗头两年的健康状况。研究对象在重复 ART 诊所就诊期间完成了标准化问卷。使用 30 天的回忆期来得出受试者健康状况不佳的天数以及疼痛导致难以完成家庭和工作中的日常活动的天数。为期 7 天的回忆期用于评估身体疼痛、恶心、疲劳和皮疹的严重程度。大多数症状的患病率随着时间的推移而下降。接受 ART 的第一个月健康状况不佳的中位数为 7 天，在第 24 个月下降到 3 天（p = 0.043）。由于疼痛导致日常活动困难，接受 ART 的第一个月的中位数为 7 天，到 12 个月时降至零（p
Improvements in physical wellbeing during the first six months on antiretroviral therapy (ART) are well known, but little is known regarding long-term follow-up. We conducted a prospective cohort study among 222 HIV-positive adult tea plantation workers in western Kenya to assess wellbeing over their first two years on ART. Study subjects completed a standardized questionnaire during repeat ART clinic visits. A 30-day recall period was used to elicit the number of days when subjects experienced poor health and the number of days that pain made it difficult to complete usual activities at home and work. A seven-day recall period was used to assess the severity of bodily pain, nausea, fatigue, and rash. Prevalence of most symptoms declined over time. A median of seven days poor health during the first month on ART declined to three days in the 24th month (p = 0.043). For pain making usual activities difficult, a median of seven days during the first month on ART fell to zero by 12 months (p