Structural and functional properties of the TRK family of neurotrophin receptors
Structural and functional properties of the TRK family of neurotrophin receptors
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DOI：
10.1111/j.1749-6632.1995.tb26693.x
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发表时间：
1995-01-01
期刊：
影响因子：
--
通讯作者：
Barbacid, M
中科院分区：
文献类型：
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作者：
Barbacid, M
酪氨酸蛋白激酶的Trk家族，TrkA、TrkB和TrkC，是介导神经营养因子的NGF家族的生物学特性的信号传导受体。这个生长因子家族除了包括NGF外，还包括BDNF、NT-3和NT-4。TrkA是NGF受体。TrkB是BDNF和NT-4的受体，TrkC是NT-3的主要受体。NT-3是一种有点混杂的配体，也可以在高浓度下激活TrkA和TrkB受体。trkB和trkC基因也编码非催化受体亚型，但功能未知。除了Trk受体之外，神经营养因子的NGF家族还以低亲和力结合到一种不相关的分子，称为p75，其是TNF受体超家族的成员。最近，我们已经产生了小鼠品系缺乏这些酪氨酸激酶受体的基因靶向胚胎干细胞。这些突变小鼠的表征提供了有关这些受体在哺乳动物神经系统个体发育中发挥关键作用的相关信息。
The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors that mediate the biological properties of the NGF family of neurotrophins. This family of growth factors includes in addition to NGF, BDNF, NT-3, and NT-4. TrkA is the NGF receptor. TrkB serves as a receptor for both BDNF and NT-4, and TrkC is the primary receptor for NT-3. NT-3 is a somewhat promiscuous ligand that can also activate TrkA and TrkB receptors at high concentrations. The trkB and trkC genes also encode noncatalytic receptor isoforms of an, as yet, unknown function. In addition to the Trk receptors, the NGF family of neurotrophins also binds with low affinity to an unrelated molecule, designated p75, a member of the TNF-receptor superfamily. Recently, we have generated strains of mice lacking each of these tyrosine-kinase receptors by gene targeting in embryonic stem cells. Characterization of these mutant mice is providing relevant information regarding the critical role that these receptors play in the ontogeny of the mammalian nervous system.