The Role of IGF-1 and Ghrelin in the Compensation of Intrauterine Growth Restriction
The Role of IGF-1 and Ghrelin in the Compensation of Intrauterine Growth Restriction
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DOI：
10.1177/1933719109344629
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发表时间：
2009-12-01
影响因子：
2.9
通讯作者：
Kanaka-Gantenbein, Christina
中科院分区：
文献类型：
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作者：
Kyriakakou, Marialena;Malamitsi-Puchner, Ariadne;Kanaka-Gantenbein, Christina
研究胰岛素样生长因子1（IGF-1）和生长素释放肽（ghrelin）在宫内生长受限（IUGR）新生儿与适合胎龄（阿加）新生儿中的作用。分别测定20例足月IUGR和20例阿加儿出生时（脐带-UC）、出生后第1天和第4天（d1和d4）的IGF-1/胰岛素样生长因子结合蛋白3（IGFBP 3）、ghrelin、胰岛素和皮质醇水平。IUGR组IGF-1与出生体重的比值高于阿加组，UC组（18.2 +/- 1.2 vs14.4 +/- 0.9，P = 0.05）和d1组（9.6 +/- 0.5 vs6.8 +/- 0.3，P = 0.05）。IGFBP 3与ghrelin呈负相关，IGFBP 1与ghrelin呈负相关，IGFBP 3与ghrelin呈负相关。在两组中，胎儿IGF-1水平与胎儿皮质醇水平呈负相关。宫内生长受限的新生儿表现出相对的IGF-1抵抗，试图以生长为代价驱动能量朝向生存。生长激素释放肽与IGF-1/IGFBP 3在出生后的相关性表明，生长激素释放肽可能在子宫内营养不足的补偿，促进出生后的生长中发挥作用。
The role of insulin-like growth factor 1 (IGF-1) and ghrelin in intrauterine growth restricted (IUGR) neonates in comparison to appropriate for gestational age (AGA) ones was investigated. Levels of IGF-1/insulin-like growth factor binding protein 3 (IGFBP3), ghrelin, insulin, and cortisol were determined in 20 singleton, full-term IUGR and 20 respective AGA neonates at birth (umbilical cord-UC), on days 1 (d1) and 4 (d4) postnatally. The ratio of IGF-1 to birth weight was higher in IUGR than in AGA in both UC (18.2 +/- 1.2 vs14.4 +/- 0.9, P = .05) and d1 (9.6 +/- 0.5 vs 6.8 +/- 0.3, P = .05). A significant positive correlation was found between IGF-1 and ghrelin levels and a negative one between IGFBP3 and ghrelin only in IUGR. In both groups, fetal IGF-1 levels negatively correlated with fetal cortisol levels. Intrauterine growth restricted neonates demonstrate a relative IGF-1 resistance in an attempt to drive energy toward survival on the expense of growth. The observed correlations between ghrelin and IGF-1/IGFBP3 postnatally indicate that ghrelin might play a role in the compensation of intrauterine undernutrition, promoting postnatal growth.