Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method
Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method
复制标题
DOI：
10.1016/j.actbio.2008.11.016
复制
发表时间：
2009-05-01
影响因子：
9.7
通讯作者：
Gradon, Leon
中科院分区：
文献类型：
--
作者：
Iskandar, Ferry;Nandiyanto, Asep Bayu Dani;Gradon, Leon
采用胶体模板法和喷雾干燥法成功制备了多孔性和孔径可控的透明质酸（HA）多孔粒子，孔径范围为100 ~ 300 nm。分别作为前驱体和模板剂的HA粉末和聚苯乙烯胶乳（PSL）颗粒在水溶液中混合，并使用双流体喷嘴系统喷雾干燥以产生HA和PSL复合颗粒。在喷雾干燥过程中使用温度为120 ℃的热空气蒸发水。这个简单的过程在几秒钟内完成。收集所制备的颗粒并用有机溶剂洗涤以溶解PSL模板剂。通过改变前体与模板剂的初始质量比，即，HA至PSL，并通过改变PSL模板颗粒的尺寸。(C)2008 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Hyaluronic acid (HA) porous particles with controllable porosity and pore size, ranging from 100 to 300 nm, were successfully prepared using a colloidal templating and spray-drying method. HA powder and polystyrene latex (PSL) particles, which were used as the precursor and templating agent, respectively, were mixed in aqueous solution and spray-dried using a two-fluid nozzle system to produce HA and PSL composite particles. Water was evaporated during spray-drying using heated air with a temperature of 120 degrees C. This simple process was completed within several seconds. The prepared particles were collected and washed with an organic solvent to dissolve the PSL templating agent. The porosity and pore size of the resulting particles were easily controlled by changing the initial mass ratio of precursor to templating agent, i.e., HA to PSL, and by altering the size of the PSL template particles. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.