Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics

Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics
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DOI：
10.1590/s1516-05722013000200008
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发表时间：
2013
期刊：
--
影响因子：
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通讯作者：
G. Negri;D. Santi;R. Tabach
G. Negri;D. Santi;R. Tabach
中科院分区：
其他
文献类型：
--
作者：
G. Negri;D. Santi;R. Tabach

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种，其中有心叶椴Tilia cordata Mill.（Tiliaceae），在民间医学中用作抗焦虑药。采用液相色谱-质谱法HPLC-DAD-ESI-MS/MS在负离子模式下分析水乙醇提取物，并将其化学组成与报道为抗焦虑药的黄酮类化合物进行比较。发现的主要黄酮类化合物为：槲皮素-3，7-二-O-鼠李糖苷、山萘酚-3，7-二-O-鼠李糖苷和山萘酚3-O-（6”-对香豆酰葡萄糖苷）或替利苷。椴树属植物的抗焦虑活性主要来自槲皮素和山奈酚衍生物的存在，而椴树属植物的抗焦虑活性主要来自槲皮素和山奈酚衍生物的存在。鳄梨的墨西哥被归因于tiliroside，这也是该物种的主要成分之一。
Tilia species, among which is Tilia cordata Mill. (Tiliaceae), have been used in folk medicine as anxiolytic. The hydroethanolic extract was analyzed by using liquid chromatography with mass spectrometry HPLC-DAD-ESI-MS/MS in negative ion mode, and its chemical composition was compared to flavonoids reported as anxiolytics. The major flavonoids found were: quercetin-3,7-di-O-rhamnoside, kaempferol-3,7-di-O-rhamnoside and kaempferol 3-O-(6"-p-coumaroyl glucoside) or tiliroside. The anxiolytic activity of the genus Tilia has been attributed to the presence of quercetin and kaempferol derivatives, while the anxiolytic activity of T. americana var. Mexicana was attributed to tiliroside, which was also found among the major constituents of this species.