Interferon gamma, IL-12, IL-12R and STAT-1 immunodeficiency diseases: disorders of the interface of innate and adaptive immunity
Interferon gamma, IL-12, IL-12R and STAT-1 immunodeficiency diseases: disorders of the interface of innate and adaptive immunity
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DOI：
10.1007/s12026-007-0045-8
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发表时间：
2007-01-01
影响因子：
4.4
通讯作者：
Holland, Steven M.
中科院分区：
文献类型：
--
作者：
Holland, Steven M.
对分枝杆菌感染的敏感性长期与T细胞免疫的缺陷有关，例如由HIV感染或医源性免疫抑制所赋予的缺陷。然而，尽管有结核病和非结核分枝杆菌对临床疾病的易感性良好，但对分枝杆菌感染的遗传疾病与非结核细菌和巴基氏菌群和巴基氏氏菌氏菌（BCG）相对特异-12生产，信号和可用性。
Susceptibility to mycobacterial infection has long been associated with defects in T cell immunity, such as those conferred by HIV infection or iatrogenic immune suppression. However, despite these well-recognized predispositions to clinical disease with tuberculosis and nontuberculous mycobacteria, the genetic disorders that are relatively specific for mycobacterial infection with nontuberculous bacteria and bacille Calmette Guerin (BCG) involve the innate immune pathways, and all engage interferon Gamma and IL-12 production, signaling, and availability.