Serum nitric oxide levels in healthy pregnant women: a case- control study in a tertiary facility in Ghana.
Serum nitric oxide levels in healthy pregnant women: a case- control study in a tertiary facility in Ghana.
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DOI：
10.1186/s40748-017-0072-y
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Aryee G
中科院分区：
文献类型：
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作者：
Owusu Darkwa E;Djagbletey R;Sottie D;Owoo C;Vanderpuye NM;Essuman R;Aryee G
怀孕与母体心血管系统的显着变化有关，心血管系统调节着对成长中的胎儿的氧气和营养供应。一氧化氮是一种生理性的血管平滑肌松弛药，调节血流，因此可能在妊娠期间的心血管变化中发挥作用。本研究旨在测定健康孕期孕妇血清一氧化氮水平及其变化。对32例健康非妊娠妇女和100例健康孕妇(早孕33例，S孕37例，晚孕30例)进行病例对照研究。在获得知情同意并符合纳入标准后，受试者被连续招募到研究中。采用Griess试剂法测定血清一氧化氮水平。在招募病例和对照组的年龄和产次方面没有统计学意义上的差异。与健康的非妊娠妇女相比，健康孕妇的平均动脉压显著降低(p = 0.009)，血清一氧化氮水平显著升高(p <； 0.001)。在健康的正常妊娠期间，血清一氧化氮水平没有明显的进行性升高。健康妊娠患者血压显著降低，血清一氧化氮水平显著升高，提示一氧化氮在妊娠血管适应中起重要作用。
Pregnancy is associated with significant changes in maternal cardiovascular system which regulates oxygen and nutrient supply to the growing foetus. Nitric oxide, a physiologic vascular smooth muscle relaxant regulates blood flow and therefore may play a role in the cardiovascular changes in pregnancy. The study aimed to determine the levels and changes in maternal serum nitric oxide levels during healthy pregnancy. A case-control study was conducted among 32 healthy non-pregnant women as controls and 100 healthy pregnant women (consisting of 33 first trimester, 37 s trimester, and 30 third trimester) as cases. Subjects were consecutively recruited into the study after obtaining an informed consent and meeting the inclusion criteria. Griess Reagent method was used to determine serum nitric oxide levels. There were no statistically significant difference in the ages and parity of recruited cases and controls. Mean arterial blood pressures were significantly lower (p = 0.009) and serum nitric oxide levels were significantly higher (p < 0.001) in healthy pregnant women compared to healthy non-pregnant women. There was a non-significant progressive increase in serum nitric oxide levels during healthy normal pregnancy. The finding of a significantly reduced blood pressures and a significant increase in serum nitric oxide levels in healthy pregnancy may suggest a role of nitric oxide in vascular adaptation in pregnancy.