Dermatomyositis associated with lymphoproliferative disorder of NK cells and occult small cell lung carcinoma
Dermatomyositis associated with lymphoproliferative disorder of NK cells and occult small cell lung carcinoma
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DOI：
10.1007/s10067-003-0814-2
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发表时间：
2004-06-01
影响因子：
3.4
通讯作者：
Airò, P
中科院分区：
文献类型：
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作者：
Antonioli, CM;Airò, P
我们报告一例皮肌炎，与循环NK细胞（CD3-CD16+）显著扩增相关，具有均匀表型（CD56- CD94- CD159a- CD244+），满足颗粒淋巴细胞/NK细胞淋巴增生性疾病的最新诊断标准。免疫抑制治疗诱导皮肌炎缓解，减少循环NK细胞的数量。然而，在皮肌炎出现时隐匿的小细胞肺癌，在10个月后被诊断出来。
We report a case of dermatomyositis that was associated with a marked expansion of circulating NK cells (CD3-CD16+) with homogeneous phenotype (CD56- CD94- CD159a- CD244+) which satisfied the updated diagnostic criteria for the lymphoproliferative disorder of granular lymphocytes/NK cells. Immunosuppressive treatment induced remission of the dermatomyositis and decreased the number of circulating NK cells. However, a small cell lung carcinoma, that was occult at the time of the presentation of dermatomyositis, was diagnosed 10 months thereafter.