HIV-associated lung infections and complications in the era of combination antiretroviral therapy.
HIV-associated lung infections and complications in the era of combination antiretroviral therapy.
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DOI：
10.1513/pats.201009-059wr
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发表时间：
2011-06-01
期刊：
影响因子：
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通讯作者：
Huang, Laurence
中科院分区：
文献类型：
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作者：
Crothers, Kristina;Thompson, Bruce W;Huang, Laurence
与HIV相关的肺部疾病的范围很广，许多HIV感染的感染性和非感染性并发症已经被认识到。自15年前艾滋病毒感染肺部并发症研究以来，在抗逆转录病毒治疗（ART）增加预期寿命之前，肺部并发症的性质和患病率尚未得到充分表征。我们对这些疾病在当前ART时代的全球流行病学的理解是有限的，特别是对非感染性疾病增加的机制还没有很好的理解。HIV相关肺部感染和并发症的纵向研究（肺部HIV）研究（ClinicalTrials.gov编号NCT 00933595）是由国家心脏、肺和血液研究所建立的多R01研究项目合作联盟，旨在检查HIV感染者的各种感染性和非感染性肺部疾病。本文回顾了我们目前对艾滋病毒对肺部健康和肺部疾病发展的影响的认识，并强调了肺部艾滋病毒研究中正在进行的研究。
The spectrum of lung diseases associated with HIV is broad, and many infectious and noninfectious complications of HIV infection have been recognized. The nature and prevalence of lung complications have not been fully characterized since the Pulmonary Complications of HIV Infection Study more than 15 years ago, before antiretroviral therapy (ART) increased life expectancy. Our understanding of the global epidemiology of these diseases in the current ART era is limited, and the mechanisms for the increases in the noninfectious conditions, in particular, are not well understood. The Longitudinal Studies of HIV-Associated Lung Infections and Complications (Lung HIV) Study (ClinicalTrials.gov number NCT00933595) is a collaborative multi-R01 consortium of research projects established by the National Heart, Lung, and Blood Institute to examine a diverse range of infectious and noninfectious pulmonary diseases in HIV-infected persons. This article reviews our current state of knowledge of the impact of HIV on lung health and the development of pulmonary diseases, and highlights ongoing research within the Lung HIV Study.