Vascular Endothelial Growth Factor-C Associated with Computed Tomography Used in the Diagnosis of Lymph Node Metastasis of Bladder Carcinoma
Vascular Endothelial Growth Factor-C Associated with Computed Tomography Used in the Diagnosis of Lymph Node Metastasis of Bladder Carcinoma
复制标题
血管内皮生长因子-C联合计算机断层扫描在膀胱癌淋巴结转移诊断中的应用
DOI：
10.1016/j.arcmed.2010.11.003
复制
发表时间：
2010-11-01
影响因子：
7.7
通讯作者：
Qi, Lin
中科院分区：
文献类型：
--
作者：
Li, Zhuo;Qi, Fan;Qi, Lin
背景和目标。血管内皮生长因子C（VEGF-C）已被证明刺激淋巴管内皮细胞的生长。本研究旨在探讨膀胱移行细胞癌（BTCC）中VEGF-C与CT的相关性及其与淋巴结转移的关系。方法：对127例膀胱移行细胞癌患者术前行腹盆部CT平扫及增强扫描，术后采用免疫组化法检测肿瘤细胞VEGF-C蛋白表达，并详细记录病理检查结果。VEGF-C在膀胱癌细胞中的表达明显高于正常膀胱上皮。BTCC阳性组VEGF-C与淋巴结转移显著相关（p
Background and Aims. Vascular endothelial growth factor C (VEGF-C) has been demonstrated to stimulate the growth of lymphatic vascular endothelium. The purpose of this study is to determine whether VEGF-C associated with computed tomography (CT) has a relationship with lymph node metastasis in bladder transitional cell carcinoma (BTCC).Methods. One hundred twenty seven cases of BTCC were studied: first, both plain and enhanced CT scans of abdomen and pelvis were performed preoperatively; second, VEGF-C protein expressions in tumor cells were tested by immunohistochemistry postoperatively; and finally, detailed pathological findings for lymph node metastasis were recorded.Results. VEGF-C expressions in tumor bladder cells were significantly higher than those in normal bladder epithelium. In the group of BTCC-positive, VEGF-C was significantly correlated with lymph node metastasis (p