Heterologous challenge in the presence of maternally-derived antibodies results in vaccine-associated enhanced respiratory disease in weaned piglets.
Heterologous challenge in the presence of maternally-derived antibodies results in vaccine-associated enhanced respiratory disease in weaned piglets.
复制标题
母源抗体存在下的异源攻击会导致断奶仔猪疫苗相关的呼吸道疾病加剧。
DOI：
10.1016/j.virol.2016.01.015
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Vincent,AmyL
中科院分区：
文献类型：
--
作者：
Rajao,DanielaS;Sandbulte,MatthewR;Gauger,PhillipC;Kitikoon,Pravina;Platt,Ratree;Roth,JamesA;Perez,DanielR;Loving,CrystalL;Vincent,AmyL
通过对雌性猪接种疫苗以通过初乳提供母源性抗体（MDA）来控制猪中的甲型流感病毒（IAV）。我们的目的是评估MDA是否干扰IAV感染、临床疾病和未接种仔猪的传播。在第一项研究中，未感染母猪接种了H1 N2-δ1全灭活病毒（WIV）疫苗。在后续研究中，对2009年大流行H1N1（H1N1 pdm 09）血清阳性的母猪用H1N1 pdm 09 WIV或二次实验感染（EXP）加强。用同源或异源病毒攻击MDA阳性猪，并包括MDA阴性对照组。保护WIV-MDA仔猪免受同源感染。然而，WIV衍生MDA仔猪随后用异源病毒攻毒，发生疫苗相关增强型呼吸道疾病（VAERD），无论母猪是否有自然暴露史。我们的数据表明，虽然高滴度的疫苗衍生的MDA减少同源病毒感染，传播和疾病，MDA单独足以诱导VAERD后异源感染。
Control of influenza A virus (IAV) in pigs is done by vaccination of females to provide maternally-derived antibodies (MDA) through colostrum. Our aim was to evaluate if MDA interfere with IAV infection, clinical disease, and transmission in non-vaccinated piglets. In the first study, naïve sows were vaccinated with H1N2-δ1 whole inactivated virus (WIV) vaccine. In a follow-up study seropositive sows to 2009 pandemic H1N1 (H1N1pdm09) were boosted with H1N1pdm09 WIV or secondary experimental infection (EXP). MDA-positive pigs were challenged with homologous or heterologous virus, and MDA-negative control groups were included. WIV-MDA piglets were protected from homologous infection. However, piglets with WIV-derived MDA subsequently challenged with heterologous virus developed vaccine associated enhanced respiratory disease (VAERD), regardless of history of natural exposure in the sows. Our data indicates that although high titers of vaccine-derived MDA reduced homologous virus infection, transmission, and disease, MDA alone was sufficient to induce VAERD upon heterologous infection.