Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy.
Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy.
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DOI：
10.1158/0008-5472.can-11-3269
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发表时间：
2012-05-01
期刊：
影响因子：
11.2
通讯作者：
Almog N
中科院分区：
文献类型：
--
作者：
Enderling H;Hahnfeldt P;Hlatky L;Almog N
几十年来，人们已经认识到肿瘤进展不是单调的，并且癌细胞的发展并不等同于临床中不可避免的癌症表现。肿瘤进展受到许多内在和外在瓶颈的挑战，这些瓶颈可以使肿瘤长时间处于休眠阶段。鉴于这些瓶颈的复杂性和多尺度性，癌症系统生物学中心组织了一个关于肿瘤休眠系统生物学关键问题的研讨会。今年7月的会议计划由纳瓦·阿尔莫格和海科·恩德林主持，包括关于血管生成调节肿瘤休眠、肿瘤免疫系统相互作用、癌症干细胞动力学和细胞信号传导途径的讨论和互动分组会议。会议得出了三个重要结论。首先是迫切需要区分原发性肿瘤和转移性沉积物的肿瘤细胞和肿瘤群体休眠，第二个是持续需要跨学科对话，第三个是需要将跨尺度机制思维带入该领域，以实现对肿瘤休眠及其临床意义的更有力理解。
For many decades it has been appreciated that tumor progression is not monotonic, and development of a cancer cell does not equate to inevitable cancer presentation in the clinic. Tumor progression is challenged by numerous intrinsic and extrinsic bottlenecks that can hold the tumor in dormant stages for prolonged periods. Given the complex, multi-scale nature of these bottlenecks, the Center of Cancer Systems Biology organized a workshop on critical issues of systems biology of tumor dormancy. The program for the meeting this past July, chaired by Nava Almog and Heiko Enderling, included discussions and interactive breakout sessions on regulation of tumor dormancy by angiogenesis, tumor-immune system interactions, cancer stem cell kinetics, and cell signaling pathways. Three important conclusions emerged from the meeting. The first was the urgent need to differentiate between tumor cell and tumor population dormancy of the primary tumor and metastatic deposits, the second was the continued need for interdisciplinary dialogs, and the third was the need to bring cross-scale mechanistic thinking to the field to achieve a more robust understanding of tumor dormancy and its clinical implications.