Measuring and interpreting ocular blood flow and metabolism in glaucoma
Measuring and interpreting ocular blood flow and metabolism in glaucoma
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DOI：
10.3129/i08-051
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发表时间：
2008-06-01
影响因子：
4.2
通讯作者：
Siesky, Brent
中科院分区：
文献类型：
--
作者：
Harris, Alon;Kagemann, Larry;Siesky, Brent
越来越多的证据表明，血管功能障碍与包括青光眼在内的几种主要眼科疾病有关。绝大多数提供眼循环和疾病病理生理学数据的研究使用相对较少的复杂眼血流成像技术。虽然这些成像技术在临床环境中并不常用，但要了解表征眼部血流的医学文献，需要熟悉其方法和功能。本文综述了最常用于研究眼血流的成像技术，包括彩色多普勒成像、荧光素和吲哚菁绿色染料共焦扫描激光眼底血管造影、佳能激光血流仪、扫描激光多普勒血流仪和视网膜摄影血氧仪。每种成像技术的能力，以确定血管功能和揭示病理进行了讨论，是每种技术固有的局限性。本综述的最终目标是为医生提供一个临床相关的基础，用于区分文献中经常出现的各种眼血流结局指标，并确定它们与眼部健康和疾病的关系。
There is a growing body of evidence suggesting that vascular dysfunction is related to several prominent ophthalmic diseases, including glaucoma. The vast majority of studies providing data on ocular circulation and disease pathophysiology use a relatively small number of complicated ocular blood flow imaging techniques. Although these imaging technologies are not commonly used in clinical settings, understanding the medical literature characterizing ocular blood flow requires familiarity with their methodology and function. This review highlights the imaging technologies most commonly used to investigate ocular blood flow, including color Doppler imaging, confocal scanning laser ophthalmoscopic angiography with fluorescein and indocyanine green dye, Canon laser blood flowmetry, scanning laser Doppler flowmetry, and retinal photographic oximetry. Each imaging technique's ability to define vascular function and reveal pathology is discussed as are limitations inherent to each technology. The ultimate goal of this review is to provide the physician with a clinically relevant foundation for differentiating the various ocular blood flow outcome measures often presented in the literature and determine how they are related to ocular health and disease.