A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
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DOI：
10.1016/0168-9525(96)10036-6
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发表时间：
1996-01-01
影响因子：
11.4
通讯作者：
Nurse, Paul
中科院分区：
文献类型：
--
作者：
Stern, Bodo;Nurse, Paul
在这篇文章中，我们考虑的作用，细胞周期蛋白依赖性蛋白激酶cdc 2在调节进程通过裂殖酵母细胞周期。有丝分裂的开始由cdc 2与B型细胞周期蛋白cdc 13共同控制。最近的证据表明，cdc 2-cdc 13复合物也可以控制S期的开始，此外，确保每个细胞周期只有一个S期。这使我们提出了一种新的定量模型，其中不同水平的cdc 2活性调节细胞周期进程：S期启动时，蛋白激酶活性从非常低的增加到中等水平，维持这种中等水平防止重新启动S期，并进一步增加活动到高水平启动有丝分裂。有丝分裂结束时激酶活性的失活使细胞重新进入新的细胞周期。
In this article we consider the role of the cyclin-dependent protein kinase cdc2 in regulating progression through the fission yeast cell cycle. The onset of mitosis is governed by cdc2 in partnership with the B-type cyclin, cdc13. Recent evidence shows that the cdc2-cdc13 complex can also control the onset of S phase and, in addition, ensures that there is only one S phase per cell cycle. This leads us to propose a novel quantitative model in which different levels of cdc2 activity regulate cell-cycle progression: S phase is initiated when protein kinase activity increases from a very low to a moderate level; maintenance of this moderate level prevents re-initiation of S phase, and a further increase of activity to a high level initiates mitosis. Inactivation of the kinase activity at the end of mitosis resets the cell for a new cell cycle.