Romancing mitosis and the mitotic apparatus
Romancing mitosis and the mitotic apparatus
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DOI：
10.1091/mbc.e14-06-1123
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发表时间：
2014-11-01
影响因子：
3.3
通讯作者：
Brinkley, William (B. R. )
中科院分区：
文献类型：
--
作者：
Brinkley, William (B. R. )
学生在生物学中最早学习的课程之一是有丝分裂的过程以及细胞如何分裂产生子细胞。虽然早在世纪以前，早期的研究者如E. B。威尔逊，有丝分裂和细胞分裂的许多方面仍然是今天大量研究的主题。我个人的调查和研究有丝分裂的研究贡献是可能的，在该领域的最新发展，当我开始我的职业生涯，包括获得新的哺乳动物细胞培养模型和电子和荧光显微镜。在这些创新的基础上，我的实验室和其他当代研究人员首先绘制了有丝分裂和染色体运动的超微结构和分子组织以及细胞骨架的组装和功能。这一研究领域仍然是未来细胞生物学和医学研究人员面临的重大挑战。
One of the earliest lessons students learn in biology is the process of mitosis and how cells divide to produce daughter cells. Although first described more than a century ago by early investigators such as E. B. Wilson, many aspects of mitosis and cell division remain the subject of considerable research today. My personal investigations and research contributions to the study of mitosis were made possible by recent developments in the field when I began my career, including access to novel mammalian cell culture models and electron and fluorescence microscopy. Building upon those innovations, my laboratory and other contemporary investigators first charted the ultrastructure and molecular organization of mitosis and chromosome movement and the assembly and function of the cytoskeleton. This field of research remains a significant challenge for future investigators in cell biology and medicine.