Ischemic myocardial dysfunction assessed by temporal Fourier transform of regional myocardial wall thickening.
Ischemic myocardial dysfunction assessed by temporal Fourier transform of regional myocardial wall thickening.
复制标题
通过局部心肌壁增厚的时间傅里叶变换评估缺血性心肌功能障碍。
DOI：
10.1016/0002-8703(87)90018-4
复制
发表时间：
1987
影响因子：
4.8
通讯作者：
RossJr,J
中科院分区：
文献类型：
--
作者：
Heusch,G;Guth,BD;Widmann,T;Peterson,KL;RossJr,J
傅立叶分析，包括前20个谐波进行sonomicrometric测量的区域心肌壁厚度在8个清醒的狗在控制条件下，并在四个层次的缺血所产生的液压封堵器的左回旋冠状动脉。结果显示，治疗组的胸壁增厚率由治疗前的26.47 ± 6.20%（S.D.）对照组为22.05 ± 5.73%（轻度狭窄）、17.00 ± 5.86%（中度狭窄）、11.46 ± 3.56%（重度狭窄）和3.69 ± 2.57%（30秒闭塞），各组间差异有显著性（p< 0.01）。一次谐波振幅从1.35 ± 0.31依次递减至1.08 ± 0.29 mm、0.90 ± 0.27 mm、0.69 ± 0.24 mm和0.43 ± 0.12 mm，差异均有统计学意义（p< 0.05）。这些振幅值与收缩期室壁增厚百分比相关（r= 0.894，p = 0.001）。一次谐波的相移从137 ± 11度到139 ± 14度、150 ± 15度（p< 0.05 vs对照），161 ± 21度（p< 0.01，对照组），191 ± 21度（与对照组和重度狭窄组相比，P< 0.01）与从舒张末期至最大室壁偏移点的时间延长相关（r= 0.662，p < 0.001）。这些数据表明，缺血性局部心肌运动功能减退的程度可以充分描述的一次谐波的振幅，并可以检测心室收缩和舒张的一次谐波的相位。
A Fourier analysis including the first 20 harmonics was performed on sonomicrometric measurements of regional myocardial wall thickness in eight conscious dogs under control conditions and at four levels of ischemia produced by a hydraulic occluder on the left circumflex coronary artery. Systolic wall thickening was reduced from 26.47 ± 6.20% (S.D.) (control) to 22.05 ± 5.73% (mild stenosis), 17.00 ± 5.86% (moderate stenosis), 11.46 ± 3.56% (severe stenosis), and 3.69 ± 2.57% (30-second occlusion), values significantly different from each other (p< 0.01). The amplitude of the first harmonic decreased stepwise from 1.35 ± 0.31 to 1.08 ± 0.29 mm, 0.90 ± 0.27 mm, 0.69 ± 0.24 mm, and 0.43 ± 0.12 mm, all significantly different from each other (p< 0.05). These amplitude values correlated to percent systolic wall thickening (r= 0.894,p= 0.001). A phase shift of the first harmonic from 137 ± 11 to 139 ± 14 degrees, 150 ± 15 degrees (p< 0.05 vs control), 161 ± 21 degrees (p< 0.01 vs control), and 191 ± 21 degrees (p< 0.01 vs control and severe stenosis) correlated with the increase in time from end diastole to the point of maximum wall excursion (r= 0.662,p< 0.001). These data indicate that the extent of ischemic regional myocardial hypokinesis can be adequately described by the amplitude of the first harmonic, and that the asynchrony of ventricular contraction and relaxation can be detected from the phase of the first harmonic.