T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis
T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis
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DOI：
10.1016/s0165-5728(99)00057-0
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发表时间：
1999-08-03
影响因子：
3.3
通讯作者：
Zhang, JWZ
中科院分区：
文献类型：
--
作者：
Kil, K;Zang, YCQ;Zhang, JWZ
继发于髓磷脂破坏的自身免疫炎症可能对脊髓损伤（SCI）神经功能的恢复起到抑制作用。在这项研究中，我们证明了识别髓磷脂碱性蛋白（MBP）的T细胞在SCI患者中以较高的前体频率出现，这与多发性硬化（MS）患者的情况一致，多发性硬化症（MS）是一种推测的自身免疫病理性疾病。研究结果表明 SCI 患者的 MBP 反应性 T 细胞过度活跃。来自 SCI 患者的 MBP 反应性 T 细胞系表现出对 MBP 81-99 和 151-169 区域的优先识别模式。来自 SCI 患者和 MS 患者的两组 MBP 反应性 T 细胞系之间的表位识别和细胞因子谱存在功能差异。该研究为进一步研究炎症成分在 SCI 中的作用提供了重要的新证据。 (C) 1999 Elsevier Science B.V. 保留所有权利。
Autoimmune inflammation secondary to myelin destruction may play an inhibitory role in restoration of nerve functions in spinal cord injury (SCI), In this study, we demonstrated that T cells recognizing myelin basic protein (MBP) occurred at a high precursor frequency in patients with SCI, which was compatible to that in patients with multiple sclerosis (MS), a disease of presumed autoimmune pathology. The findings suggest of hyperactivity of MBP-reactive T cells in patients with SCI. MBP-reactive T cell lines derived from patients with SCI exhibited a preferential recognition pattern toward the 81-99 and the 151-169 regions of MBP. There were functional differences in the epitope recognition and cytokine profile between two panels of MBP-reactive T cell lines derived from patients with SCI and patients with MS. The study provides new evidence important for further investigation of the role of the inflammatory component in SCI. (C) 1999 Elsevier Science B.V. All rights reserved.