Haloperidol, dynamics of choice, and the parameters of the matching law
Haloperidol, dynamics of choice, and the parameters of the matching law
复制标题
DOI：
10.1016/j.beproc.2007.02.024
复制
发表时间：
2007-06-01
影响因子：
1.3
通讯作者：
Aparicio, Carlos F.
中科院分区：
文献类型：
--
作者：
Aparicio, Carlos F.
多巴胺介导刺激的强化效应的想法在神经科学领域一直存在。目前的研究表明，氟哌啶醇，多巴胺拮抗剂，并没有消除食品添加剂的强化价值。在会话内的两个杠杆中，参与者的比例变化了七次，模拟了一个动态环境。的幅度的操纵独立于的比。在12个每日疗程期间评估了4种剂量的腹膜内氟哌啶醇。氟哌啶醇并没有损害大鼠在富和瘦杠杆之间建立的区分;反应分布有利于与更高的强化概率和更大的颗粒相关的杠杆。广义匹配律的参数（偏差和灵敏度）被用来估计氟哌啶醇对运动系统和对大鼠的食物刺激动机的影响。(c)2007 Elsevier B. V.保留所有权利。
The idea that dopamine mediates the reinforcing effects of stimuli persists in the field of neurosciences. The present study shows that haloperidol, a dopamine antagonist, does not eliminate the reinforcing value of food reinforcers. The ratio of reinforcers changed seven times across two levers within sessions, modeling a dynamic environment. The magnitude of the reinforcer was manipulated independently of the reinforcer ratio. Four doses of intraperitoneal haloperidol were assessed over periods of 12 daily sessions. Haloperidol did not impair the discrimination that the rats established between rich and lean levers; the response distributions favored the lever associated with the higher probability of reinforcement and the larger pellets. The parameters of the generalized matching law (bias and sensitivity) were used to estimate effects of haloperidol upon the motor system and upon the rats' motivation for food reinforcers. (c) 2007 Elsevier B.V. All rights reserved.