The influence of BMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration
The influence of BMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration
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DOI：
10.1016/j.biomaterials.2007.02.003
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发表时间：
2007-06-01
期刊：
影响因子：
14
通讯作者：
Hunziker, Ernst B.
中科院分区：
文献类型：
--
作者：
Liu, Yuelian;Enggist, Lukas;Hunziker, Ernst B.
成骨剂，例如骨形态发生蛋白-2 (BMP-2)，可以刺激骨的降解和形成。因此，它们可能会损害功能化种植体表面的骨传导性。我们评估了 BMP-2 及其递送方式对裸钛表面或磷酸钙涂层种植体骨传导性的影响。裸露的钛表面孔吸附了BMP-2，而涂覆的钛表面孔并入、吸附或并入并吸附了BMP-2。将植入物插入成年小型猪的上颌骨中。 1-3周后，在定义的“骨传导”（种植体周围）空间内沉积的骨体积以及界定该空间的种植体表面的骨覆盖率在形态测量上进行估计。3周后，不含有BMP-2的涂层和未涂层种植体的骨传导空间内沉积的骨体积最高，其次是含有掺入BMP-2的涂层种植体；对于仅吸附 BMP-2 的涂层植入物而言，该值最低。不含有 BMP-2 的涂层植入物的骨界面覆盖率最高，其次是含有掺入或掺入并吸附 BMP-2 的涂层植入物；对于带有吸附的 BMP-2 的未涂层植入物而言，该值最低。因此，BMP-2 及其递送方式可以显着调节种植体表面的骨传导性。 (c) 2007 Elsevier Ltd. 保留所有权利。
Osteogenic agents, such as bone morphogenetic protein-2 (BMP-2), can stimulate the degradation as well as the formation of bone. Hence, they could impair the osteoconductivity of functionalized implant surfaces.We assessed the effects of BMP-2 and its mode of delivery on the osteoconductivity of dental implants with either a naked titanium surface or a calcium-phosphate-coated one. The naked titanium surface bore adsorbed BMP-2, whilst the coated one bore incorporated, adsorbed, or incorporated and adsorbed BMP-2. The implants were inserted into the maxillae of adult miniature pigs. The volume of bone deposited within a defined "osteoconductive" (peri-implant) space, and bone coverage of the implant surface delimiting this space, were estimated morphometrically 1-3 weeks later.After 3 weeks, the volume of bone deposited within the osteoconductive space was highest for coated and uncoated implants bearing no BMP-2, followed by coated implants bearing incorporated BMP-2; it was lowest for coated implants bearing only adsorbed BMP-2. Bone-interface coverage was highest for coated implants bearing no BMP-2, followed by coated implants bearing either incorporated, or incorporated and adsorbed BMP-2; it was lowest for uncoated implants bearing adsorbed BMP-2. Hence, the osteoconductivity of implant surfaces can be significantly modulated by BMP-2 and its mode of delivery. (c) 2007 Elsevier Ltd. All rights reserved.