Endothelium-dependent vasodilation in well-developed coronary collateral vessels.
Endothelium-dependent vasodilation in well-developed coronary collateral vessels.
复制标题
发达的冠状侧支血管中内皮依赖性血管舒张。
DOI：
10.1097/00005344-199610000-00002
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发表时间：
1996
影响因子：
3
通讯作者：
Bache,RJ
中科院分区：
文献类型：
--
作者：
Dulas,D;Altman,JD;Hirata-Dulas,C;Bache,RJ
我们检测了发育良好的冠状动脉侧支血管的内皮依赖性血管舒张反应。在冠状动脉左前降支（LAD）置入空心栓塞刺激侧支血管生长后6个月，从犬心脏分离侧支血管和大小匹配的正常心外膜冠状动脉。分离血管段并在器官室中研究。用前列腺素F2 α（PGF 2α）预缩血管后，测定PGF 2α对内皮依赖性血管扩张剂乙酰胆碱（ACh）、P物质、缓激肽（BK）和非内皮依赖性血管扩张剂硝酸甘油（NTG）的反应。侧支血管对ACh的最大舒张（收缩前张力的129±3.6%）大于正常血管（110± 6.2%）（p< 0.001），但侧支血管和正常血管对ACh的EC 50值无显著差异。侧支血管对BK的敏感性与正常血管相似，但侧支血管的最大舒张（收缩前张力的138±4.6%）大于正常血管（收缩前张力的108± 5.0%，p< 0.05）。P物质和NTG都产生了剂量相关的舒张作用，这在侧支血管和正常动脉中是相似的。这些结果表明，内皮依赖性舒张是完整的发达的冠状动脉侧支血管。
We examined endothelium-dependent vasodilator responses in well-developed coronary collateral vessels. Collateral vessels and size-matched normal epicardial coronary arteries were isolated from canine hearts 6 months after a hollow plug had been introduced into the left anterior descending coronary artery (LAD) to stimulate collateral vessel growth. Vessel segments were isolated and studied in organ chambers. After preconstriction with prostaglandin F 2α,(PGF 2α) responses to the endothelium-dependent vasodilators, acetylcholine (ACh), substance P, and bradykinin (BK), as well as the endothelium-independent vasodilator nitroglycerin (NTG), were measured. The maximum relaxation to ACh was greater in collateral vessels (129±3.6% of the preconstricted tension) than in normal vessels (110±6.2%, p< 0.001), although the EC 50 value for ACh was not significantly different between collateral and normal vessels. Collateral vessels demonstrated sensitivity to BK similar to that of normal vessels, but the maximal vasodilation achieved was greater in collaterals (138±4.6% of preconstricted tension) than in normal vessels (108±5.0%, p< 0.05). Both substance P and NTG produced dose-related relaxation that was similar in collateral vessels and normal arteries. These findings demonstrate that endothelium-dependent relaxation is intact in well-developed coronary collateral vessels.