The Irre Cell Recognition Module (IRM) Proteins
The Irre Cell Recognition Module (IRM) Proteins
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DOI：
10.1080/01677060802471668
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发表时间：
2009-01-01
影响因子：
1.9
通讯作者：
Chaudhary, Kokil
中科院分区：
文献类型：
--
作者：
Fischbach, Karl-Friedrich;Linneweber, Gerit Arne;Chaudhary, Kokil
发育神经科学中最具挑战性的问题之一是了解神经柱中轴突、树突和胶质过程之间特异性膜接触的建立和维持，这些接触最终确保神经元的连接。然而，潜在的细胞识别事件在其他组织中也是关键的。这篇简短的评论集中在一个小的，进化上保守的免疫球蛋白超家族的蛋白质参与细胞识别的多效性功能。在果蝇中，该蛋白质家族包括不规则交叉C/Roughest（IrreC/Rst）、irre家族（Kirre）以及它们的相互作用蛋白质伴侣，棒和石（SNS）和Hibris（Hbs）。为了简单起见，我们建议将这个蛋白质集合命名为irre细胞识别模块（irre cell recognition module，IRRE），以纪念这个家族的第一个成员。在这里，我们总结的证据表明，在各种细胞的相互作用，包括成肌细胞融合，细胞分选，轴突寻路，并在视神经柱的果蝇的目标识别的cDNA 3蛋白的功能。了解神经纤维蛋白的功能将有助于解开感觉神经柱中复杂的神经突网络形成的表观遗传规则。
One of the most challenging problems in developmental neurosciences is to understand the establishment and maintenance of specific membrane contacts between axonal, dendritic, and glial processes in the neuropils, which eventually secure neuronal connectivity. However, underlying cell recognition events are pivotal in other tissues as well. This brief review focuses on the pleiotropic functions of a small, evolutionarily conserved group of proteins of the immunoglobulin superfamily involved in cell recognition. In Drosophila, this protein family comprises Irregular chiasm C/Roughest (IrreC/Rst), Kin of irre (Kirre), and their interacting protein partners, Sticks and stones (SNS) and Hibris (Hbs). For simplicity, we propose to name this ensemble of proteins the irre cell recognition module (IRM) after the first identified member of this family. Here, we summarize evidence that the IRM proteins function together in various cellular interactions, including myoblast fusion, cell sorting, axonal pathfinding, and target recognition in the optic neuropils of Drosophila. Understanding IRM protein function will help to unravel the epigenetic rules by which the intricate neurite networks in sensory neuropils are formed.