Serum Heme Oxygenase-1 as a Marker of Lung Function Decline in Patients With Chronic Silicosis
Serum Heme Oxygenase-1 as a Marker of Lung Function Decline in Patients With Chronic Silicosis
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DOI：
10.1097/jom.0b013e3182636e93
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发表时间：
2012-12-01
影响因子：
3.2
通讯作者：
Ishigatsubo, Yoshiaki
中科院分区：
文献类型：
--
作者：
Sato, Takashi;Saito, Yoshiaki;Ishigatsubo, Yoshiaki
目的：确定慢性矽肺患者一秒用力呼气量（FEV1）过度下降的预测因素。方法：对2004年入组的46名男性患者进行筛查并接受肺功能检查。结果：在纳入的 33 名患者中，12 名被归类为快速下降者（FEV1 下降 > 60 mL/年）。快速下降者的血清血红素加氧酶-1 (HO-1)（氧化应激标志物）的平均水平显着低于正常下降者（P = 0.002）。 Logistic 回归分析显示，血清 HO-1 是影响临床上重要的 FEV1 下降的因素（比值比 = 0.52；95% 置信区间，0.31 至 0.88），与年龄、身高、体重、吸烟、暴露状况和 C 反应蛋白的影响无关。结论：血清HO-1可能是矽肺患者肺功能下降的预测指标。
Objective: To identify predictive factors of excess decline in forced expiratory volume in one second (FEV1) in patients with chronic silicosis. Methods: Forty-six male patients enrolled in 2004 were screened and received pulmonary function tests. Results: Among the 33 included patients, 12 were categorized as rapid decliners (reduction in FEV1 > 60 mL/yr). The mean level of serum heme oxygenase-1 (HO-1), a marker of oxidative stress, was significantly lower in rapid decliners than in normal decliners (P = 0.002). Logistic regression analysis revealed that serum HO-1 was a factor affecting clinically important decline in FEV1 (odds ratio = 0.52; 95% confidence interval, 0.31 to 0.88) independent of the effects of age, height, weight, smoking, exposure status, and C-reactive protein. Conclusions: Serum HO-1 may be a predictor of lung function decline in silicosis patients.