Another twist to the GLI code.
Another twist to the GLI code.
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DOI：
10.1042/bcj20200617
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发表时间：
2020-11
期刊：
影响因子：
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通讯作者：
Alex J. Timmis;Natalia A. Riobo-Del Galdo
中科院分区：
文献类型：
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作者：
Alex J. Timmis;Natalia A. Riobo-Del Galdo
典型的Hedgehog（Hh）信号通路是脊椎动物发育所必需的，其不受控制的激活在人类癌症中很常见。Hh信号传导会聚在转录因子家族GLI 1、GLI 2和GLI 3的修饰中，以协调细胞类型和环境特异性转录应答。尽管与非常相似的反应元件结合，GLI家族成员可以发挥多种甚至相反的功能。Tolosa等人最近的一篇文章（Biochem.J.477，3131-3145，2020）通过GLI 1和GLI 2之间的物理和功能相互作用揭示了一个意想不到的复杂层。这篇评论讨论了这些发现的生物学意义，并将其纳入更新的“GLI代码”。
The canonical Hedgehog (Hh) signalling pathway is essential for vertebrate development and its uncontrolled activation is a common occurrence in human cancers. Hh signalling converges in the modification of a family of transcription factors, GLI1, GLI2 and GLI3, to orchestrate a cell type and context-specific transcriptional response. Despite binding to very similar responsive elements, the GLI family members can exert diverse and even opposing functions. A recent article by Tolosa et al. (Biochem. J. 477, 3131-3145, 2020) reveals an unexpected layer of complexity, through physical and functional interaction between GLI1 and GLI2. This commentary discusses the biological significance of the findings and incorporates them into an updated 'GLI code'.