Potential Therapeutic Efficacy of Curcumin in Liver Cancer
Potential Therapeutic Efficacy of Curcumin in Liver Cancer
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DOI：
10.7314/apjcp.2013.14.6.3855
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Li, Xiang-Cheng
中科院分区：
文献类型：
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作者：
Dai, Xin-Zheng;Yin, Hai-Tao;Li, Xiang-Cheng
Purpose: Liver cancer, one of the most common cancers in China, is reported to feature relatively high morbidity and mortality. Curcumin (Cum) is considered as a drug possessing anti-angiogenic, anti-inflammation and anti-oxidation effect. Previous research has demonstrated antitumor effects in a series of cancers. Materials and Methods: In this study the in vitro cytotoxicity of Cum was measured by MTT assay and pro-apoptotic effects were assessed by DAPI staining and measurement of caspase-3 activity. In vivo anti-hepatoma efficacy of Cum was assessed with HepG2 xenografts. Results: It is found that Cum dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis. Moreover, Cum delayed the growth of liver cancer in a dose-dependent manner in nude mice. Conclusions: Cum might be a promising phytomedicine in cancer therapy and further efforts are needed to explore this therapeutic strategy.
