Hepatocellular carcinoma: focus on different aspects of management.
Hepatocellular carcinoma: focus on different aspects of management.
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DOI：
10.5402/2012/421673
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Yuxiang C
中科院分区：
文献类型：
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作者：
Waly Raphael S;Yangde Z;Yuxiang C
肝细胞癌（HCC）是全球第五大常见癌症，也是癌症相关死亡的第三大原因。其发病率显然是由主要危险因素（主要是乙型肝炎和丙型肝炎）的流行引起的，危险人群由处于广泛纤维化或肝硬化阶段的慢性肝病患者组成。这一人群的监测项目使得疾病管理的早期发现能够促进根治性治疗。了解癌变过程和掌握分期系统仍然是HCC诊断和治疗的关键。最近在诊断和新治疗方面的进展通过提高HCC患者的生存率和改善生活质量对疾病产生了重要影响。本文概述了HCC的不同管理方面，包括流行病学、预防、癌变、分期系统、诊断、监测和治疗。
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third cause of cancer-related mortality worldwide. Its incidence is clearly arising comprised by the prevalence of major risk factors mainly hepatitis B and hepatitis C. The population at risk is composed of chronic liver patients at the stage of extensive fibrosis or cirrhosis. The monitoring programs of this population have allowed early detection of disease management to promote a radical therapy. Understanding the carcinogenic process and the mastery of the staging systems remain essential keys in diagnosis and treatment of HCC. Recent advances in diagnosis and new treatments have made important impacts on the disease by increasing survival rates and improving quality of life for HCC patients. This paper outlines the different management aspects of HCC which include epidemiology, prevention, carcinogenesis, staging systems, diagnosis, surveillance, and the treatment.