Odor Identification Test as an Indicator of Idiopathic REM Sleep Behavior Disorder
Odor Identification Test as an Indicator of Idiopathic REM Sleep Behavior Disorder
复制标题
DOI：
10.1002/mds.22361
复制
发表时间：
2009-01-30
影响因子：
8.6
通讯作者：
Hirata, Koichi
中科院分区：
文献类型：
--
作者：
Miyamoto, Tomoyuki;Miyamoto, Masayuki;Hirata, Koichi
特发性快速眼动（REM）睡眠行为障碍（iRBD）患者的嗅觉功能下降与帕金森病（PD）和路易体痴呆（DLB）患者的嗅觉功能下降程度相同。我们使用日本人嗅棒识别试验（OSIT-J）评估了48例iRBD、21例PD和34例阻塞性睡眠呼吸暂停综合征（OSAS）患者的嗅觉功能。OSIT-J的可能评分范围为0 - 12。iRBD患者的OSIT-J评分为4.9 +/- 2.8，PD患者为4.8 +/- 2.8，OSAS患者为9.9 +/- 1.4。OSIT-J评分为8.5时，敏感性分别为88.2%和85.3%，特异性分别为83.3%和85.7%。分别用于区分iRBD或PD患者与OSAS患者。日本iRBD和PD患者的气味识别受损。结果表明，OSIT-J，这是一个简短而简单的非词汇嗅觉识别测试，可以作为一个有用的临床指标iRBD与路易体形成，是适合日本老年人群。(C)2008运动障碍协会
Reduction of olfactory function in idiopathic rapid-eye-movement (REM) sleep behavior disorder (iRBD) is of the same Magnitude as that found in patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We assessed olfactory function using the Odor Stick Identification Test for Japanese (OSIT-J) in 48 Japanese patients with iRBD, 21 with PD, and 34 with obstructive sleep apnea syndrome (OSAS). Possible score of the OSIT-J ranges from 0 to 12. OSIT-J scores were 4.9 +/- 2.8 in patients with iRBD, 4.8 +/- 2.8 in patients with PD, and 9.9 +/- 1.4 in OSAS patients. An OSIT-J score of 8.5 was associated with a sensitivity of 88.2 and 85.3%, respectively, and specificity of 83.3 and 85.7%. respectively, in differentiating iRBD or PD patients from OSAS patients. Odor identification is impaired in Japanese patients with iRBD and PD. The results suggest that OSIT-J, which is a short and simple nonlexical olfactory identification test, can be useful as a clinical indicator for iRBD with Lewy body formation and is appropriate in the Japanese elderly population. (C) 2008 Movement Disorder Society