Toxicity of adenine arabinoside in humans.
Toxicity of adenine arabinoside in humans.
复制标题
腺嘌呤阿糖苷对人体的毒性。
DOI：
10.1093/infdis/133.supplement_2.a192
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
C. Balakrishnan
中科院分区：
文献类型：
--
作者：
A. Ross;A. Julià;C. Balakrishnan
在两年的时间里，在 42 名接受水痘带状疱疹或单纯疱疹病毒复杂感染治疗的患者（其中 19 名患有淋巴瘤、白血病或其他恶性肿瘤）中观察到了六种形式的腺嘌呤阿拉伯糖苷（阿糖腺苷）的可逆不良反应。六名患者接受了安慰剂。 10名患者每天接受10毫克阿糖腺苷/公斤；三人接受 15 毫克/公斤； 22 人接受 20 毫克/公斤；其中一名接受了 30 毫克/公斤的剂量。患者平均接受治疗（通过连续静脉注射）7天。毒性反应包括恶心、呕吐、体重减轻、虚弱（通常伴有行走障碍）、骨髓中红系巨幼细胞增多症、治疗开始后五至七天的震颤（包括一名脑电图异常的患者出现震颤，与中毒性代谢性脑病一致）以及静脉注射部位的血栓性静脉炎。每天接受 20 mg/kg 剂量的患者中，副作用明显占主导地位。因此，在毒性与剂量水平的关系得到澄清之前，每天 10 mg/kg 的治疗似乎更可取。
Six forms of reversible adverse reactions to adenine arabinoside (vidarabine) were observed in a two-year period among 42 patients (19 of whom had lymphomas, leukemias, or other malignancies) who were treated for complicated infections with varicella-zoster or herpes simplex virus. Six patients received placebo. Ten patients received 10 mg of adenine arabinoside/kg per day; three received 15 mg/kg; 22 received 20 mg/kg; and one received 30 mg/kg. Patients were treated (by continuous intravenous injection) for an average of seven days. Toxic effects were nausea and vomiting, weight loss, weakness (often with impaired ambulation), megaloblastosis in erythroid series in bone marrow, tremors five to seven days after the start of therapy (including tremors in one patient with abnormal electroencephalograms that were consistent with toxic-metabolic encephalopathy), and thrombophlebitis at the intravenous site. Side effects clearly predominated in patients who received 20 mg/kg per day. Therefore, treatment with 10 mg/kg per day appears preferable until the relation of toxicity to dosage level can be clarified.